Mouse Beta Klotho Protein (KLB-MM101)
Mouse Beta Klotho Protein (KLB-MM101)
  • Express System: HEK293
  • Product Tag: C-His
  • Purity: >90% as determined by Bis-Tris PAGE; >90% as determined by HPLC
  • Activity: The affinity constant of 36.97 nM as determined in SPR assay (Biacore T200). See testing image for detail.
  • Amino Acid Range: Phe53-Pro994
Catalog #KLB-MM101
Regular price $330.00
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Product Description
Recombinant Mouse Beta Klotho Protein is expressed from HEK293 with His tag at the C-Terminus; It contains Phe53-Pro994.
Product Background
Beta-klotho (KLB) is a coreceptor required for endocrine fibroblast growth factor (FGF) 15/19 and FGF21 signaling in the brain. Klb is prominent within the hypothalamus, which is consistent with its metabolic functions, but diverse roles for Klb are now emerging. Central Klb expression is low but discrete and may govern FGF-targeted sites.
Product Category
Recombinant Protein
Target
Beta Klotho
Synonyms
betaKlotho; beta-klotho; BKL; KLB; klotho beta like; Klotho beta; MGC142213;βKlotho; β-klotho; klotho β like; Klotho β
Accession
Species
Mouse
Biotinylated
no
Amino Acid Range
Phe53-Pro994
Molecular Weight
The protein has a predicted MW of 109.91 kDa. Due to glycosylation, the protein migrates to 120-130 kDa based on Bis-Tris PAGE result.
Activity
The affinity constant of 36.97 nM as determined in SPR assay (Biacore T200). See testing image for detail.
Product Tag
C-His
Express System
HEK293
Purity
>90% as determined by Bis-Tris PAGE; >90% as determined by HPLC
Endotoxin
Less than 1 EU per ug by the LAL method.
Form
Lyophilized
Shipping
Shipped at ambient temperature.
Formulation
Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage
Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Human FGFR4, hFc Tag captured on CM5 Chip via Protein A can bind Mouse Beta Klotho, His Tag with an affinity constant of 36.97 nM as determined in SPR assay (Biacore T200).
Mouse Beta Klotho on Bis-Tris PAGE under reduced condition. The purity is greater than 90%.
The purity of Mouse Beta Klotho Protein is greater than 90% as determined by SEC-HPLC.

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