Mouse Beta Klotho Protein (KLB-MM101)

Express System: HEK293
Product Tag: C-His
Purity: > 90% as determined by Tris-Bis PAGE; > 90% as determined by HPLC
Activity: The affinity constant of 36.97 nM as determined in SPR assay (Biacore T200). See testing image for detail.
Amino Acid Range: Phe53-Pro994

Catalog: KLB-MM101

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Product Description	Recombinant Mouse Beta Klotho Protein is expressed from HEK293 with His tag at the C-Terminus; It contains Phe53-Pro994.
Product Background	Beta-klotho (KLB) is a coreceptor required for endocrine fibroblast growth factor (FGF) 15/19 and FGF21 signaling in the brain. Klb is prominent within the hypothalamus, which is consistent with its metabolic functions, but diverse roles for Klb are now emerging. Central Klb expression is low but discrete and may govern FGF-targeted sites.
Product Category	Recombinant Protein

Target	Beta Klotho
Accession	Q99N32-1
Species	Mouse
Amino Acid Range	Phe53-Pro994
Molecular Weight	The protein has a predicted MW of 109.91 kDa. Due to glycosylation, the protein migrates to 120-130 kDa based on Tris-Bis PAGE result.
Activity	The affinity constant of 36.97 nM as determined in SPR assay (Biacore T200). See testing image for detail.
Product Tag	C-His
Express System	HEK293
Purity	> 90% as determined by Tris-Bis PAGE; > 90% as determined by HPLC
Endotoxin	Less than 1 EU per ug by the LAL method.

Form	Liquid
Shipping	Shipped with dry ice.
Formulation	Supplied as 0.22 um filtered solution in PBS (pH 7.4).
Stability And Storage	Valid for 12 months from date of receipt when stored at -80°C; Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

	Human FGFR4, hFc Tag captured on CM5 Chip via Protein A can bind Mouse Beta Klotho, His Tag with an affinity constant of 36.97 nM as determined in SPR assay (Biacore T200).
	The purity of Mouse Beta Klotho Protein is greater than 90% as determined by SEC-HPLC.
	Mouse Beta Klotho on Tris-Bis PAGE under reduced condition. The purity is greater than 90%.