Mouse Beta Klotho Protein (KLB-MM101)

  • Express System: HEK293
  • Product Tag: C-His
  • Purity: > 90% as determined by Tris-Bis PAGE;> 90% as determined by HPLC
  • Activity: The affinity constant of 36.97 nM as determined in SPR assay (Biacore T200). See testing image for detail.
  • Exact Sequence: Phe53-Pro994

Catalog: KLB-MM101

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Product Description Recombinant Mouse Beta Klotho Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Phe53-Pro994.

Product Background

Beta-klotho (KLB) is a coreceptor required for endocrine fibroblast growth factor (FGF) 15/19 and FGF21 signaling in the brain. Klb is prominent within the hypothalamus, which is consistent with its metabolic functions, but diverse roles for Klb are now emerging. Central Klb expression is low but discrete and may govern FGF-targeted sites.

Product Category

Recombinant Protein

Target

Beta Klotho
Accession

Species

Mouse

Exact Sequence

Phe53-Pro994
Molecular Weight The protein has a predicted MW of 109.91 kDa. Due to glycosylation, the protein migrates to 120-130 kDa based on Tris-Bis PAGE result.

Activity

The affinity constant of 36.97 nM as determined in SPR assay (Biacore T200). See testing image for detail.

Product Tag

C-His

Express System

HEK293
Purity > 90% as determined by Tris-Bis PAGE;> 90% as determined by HPLC
Endotoxin Less than 1EU per ug by the LAL method.
Form Liquid
Shipping Shipped with dry ice.
Formulation Supplied as 0.22um filtered solution in PBS (pH 7.4).
Stability And Storage Valid for 12 months from date of receipt when stored at -80°C.; Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Human FGFR4, hFc Tag captured on CM5 Chip via Protein A can bind Mouse Beta Klotho, His Tag with an affinity constant of 36.97 nM as determined in SPR assay (Biacore T200).
The purity of Mouse Beta Klotho Protein is greater than 90% as determined by SEC-HPLC.
Mouse Beta Klotho on Tris-Bis PAGE under reduced condition. The purity is greater than 90%.

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