Mouse CD45/PTPRC Protein (PTP-MM201)

  • Express System: HEK293
  • Product Tag: C-hFc
  • Purity: > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
  • Exact Sequence: Gln26-Lys427

Catalog: PTP-MM201

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Product Description Recombinant Mouse CD45/PTPRC Protein is expressed from HEK293 with hFc tag at the C-Terminus.It contains Gln26-Lys427.

Product Background

PTPRC (also known as CD45),T cells require the protein tyrosine phosphatase CD45 to detect and respond to antigen because it activates the Src family kinase Lck, which phosphorylates the T cell antigen receptor (TCR) complex. CD45 ativates Lck by opposing the negative regulatory kinase Csk. Paradoxically, CD45 has also been implicated in suppressing TCR signaling by dephosphorylating the same signaling motifs within the TCR complex upon which Lck acts.

Product Category

Recombinant Protein

Target

CD45/PTPRC

Gene/Protein ID

P06800-6

Species

Mouse

Exact Sequence

Gln26-Lys427
Molecular Weight The protein has a predicted MW of 71.46 kDa. Due to glycosylation, the protein migrates to 100-130 kDa based on Tris-Bis PAGE result.

Product Tag

C-hFc

Express System

HEK293
Purity > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
Endotoxin Less than 1EU per ug by the LAL method.
Form Lyophilized
Shipping Shipped at ambient temperature.
Formulation Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
The purity of Mouse CD45 is greater than 95% as determined by SEC-HPLC.
Mouse CD45 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

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