Product Description |
Recombinant Mouse CD8 alpha&beta Heterodimer Protein is expressed from HEK293 with His tag and Flag tag at the C-terminus.It contains Lys28-Tyr196(CD8 alpha) acidic tail and Leu22-Thr175(CD8 beta) basic tail. |
Product Background |
CD8 alpha&beta (CD8αβ) is a heterodimeric form of CD8. CD8α is required for surface expression of CD8β. The extracellular IgV-like domain of CD8α interacts with the α3 portion of the class I MHC molecule. CD8αβ is expressed on human peripheral T cells and functions as a coreceptor and can greatly increase the sensitivity and breadth of antigen recognition by CD8+ peripheral T cells bearing TCR. |
Product Category |
Recombinant Protein |
Target |
CD8 alpha&beta |
Accession |
|
Species |
Mouse |
Biotinylated |
no |
Amino Acid Range |
Lys28-Tyr196(CD8 alpha) acidic tail & Leu22-Thr175(CD8 beta) basic tail |
Molecular Weight |
The protein has a predicted MW of 24.80 kDa (CD8 alpha) and 23.17 kDa (CD8 beta). Due to glycosylation, the protein migrates to 32-38 kDa (CD8 alpha) and 42-50 kDa (CD8 beta) based on Bis-Tris PAGE result. |
Product Tag |
C-His-Flag |
Express System |
HEK293 |
Purity |
> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC |
Endotoxin |
Less than 1EU per ug by the LAL method. |
Form |
Lyophilized |
Shipping |
Shipped at ambient temperature. |
Formulation |
Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution |
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
Stability And Storage |
Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
|
|
Mouse CD8 alpha&beta Heterodimer on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
|
|
The purity of Mouse CD8 alpha&beta Heterodimer is greater than 95% as determined by SEC-HPLC. |
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