Product Description |
Recombinant Mouse CD8 alpha/CD8A Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Lys28-Tyr196. |
Product Background |
CD8 alpha enhances the responses of antigen-specific CTL activated through TCR through binding MHC class I, favoring lipid raft partitioning of TCR, and inducing intracellular signaling. CD8 alpha is also found on dendritic cells and rat macrophages, but whether CD8 alpha enhances responses of a partner receptor, like TCR, to activate these cells is not known. |
Product Category |
Recombinant Protein / Antibody discovery / CAR-T targets |
Protein |
CD8 alpha/CD8A |
Synonyms |
CD8a; Lyt-2; CD8; Leu2; MAL; p32; CD8a molecule; OKT8 T-cell antigen |
Accession |
|
Species |
Mouse |
Biotinylated |
no |
Amino Acid Range |
Lys28-Tyr196 |
Molecular Weight |
The protein has a predicted MW of 20 kDa. Due to glycosylation, the protein migrates to 32-42 kDa based on Bis-Tris PAGE result. |
Product Tag |
C-His |
Expression System |
HEK293 |
Purity |
> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC |
Endotoxin |
Less than 1EU per ug by the LAL method. |
Form |
Lyophilized |
Shipping |
Shipped at ambient temperature. |
Formulation |
Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution |
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
Stability And Storage |
-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
|
|
Mouse CD8 alpha on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
|
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The purity of Mouse CD8 alpha is greater than 95% as determined by SEC-HPLC. |
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