Mouse CD96/TACTILE Protein (CD9-MM196)

  • Express System: HEK293
  • Product Tag: C-His
  • Purity: > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
  • Amino Acid Range: Val22-Met536

Catalog: CD9-MM196

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Product Description Recombinant Mouse CD96/TACTILE Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Val22-Met536.

Product Background

The receptors CD96 and TIGIT are expressed on the surface of T and natural killer (NK) cells, and recent studies suggest both play important inhibitory roles in immune function. CD96 has been shown to modulate immune cell activity in mice, with Cd96-/- mice displaying hypersensitive NK-cell responses to immune challenge and significant tumor resistance. The counterbalance between the putative inhibitory CD96 and TIGIT receptors and the activating receptor, CD226, offers unique strategies for immuno-oncology drug development.

Product Category

Recombinant Protein

Target

CD96/TACTILE
Synonyms CD96 molecule; CD96; DKFZp667E2122; TACTILE
Accession

Species

Mouse

Amino Acid Range

Val22-Met536
Molecular Weight The protein has a predicted MW of 57.9 kDa. Due to glycosylation, the protein migrates to 90-130 kDa based on Tris-Bis PAGE result.

Product Tag

C-His

Express System

HEK293
Purity > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
Endotoxin Less than 1EU per ug by the LAL method.
Form Lyophilized
Shipping Shipped at ambient temperature.
Formulation Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
The purity of Mouse CD96 is greater than 95% as determined by SEC-HPLC.
Mouse CD96 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

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