Name: Mouse CTLA-4/CD152 Protein (CTL-MM141)
Brand: KactusBio
SKU: CTL-MM141-100UG
Price: 113.0 USD
Availability: InStock

Express System: HEK293
Product Tag: C-His
Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Activity: Immobilized Mouse CTLA-4, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Human B7-1, hFc Tag (Cat. B71-HM280) with the EC50 of 1.9ng/ml determined by ELISA.
Amino Acid Range: Glu36-Asp161

Catalog #CTL-MM141

Size

100UG

500UG

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Mouse CTLA-4/CD152 Protein (CTL-MM141) Summary

Product Description	Recombinant Mouse CTLA-4/CD152 Protein is expressed from HEK293 with His tag at the C-terminus.It contains Glu36-Asp161.
Product Background	CTLA-4 (cytotoxic T-lymphocyte-associated protein 4), also known as CD152, is a protein receptor that, functioning as an immune checkpoint, downregulates immune responses.CTLA4 is constitutively expressed in regulatory T cells but only upregulated in conventional T cells after activation – a phenomenon which is particularly notable in cancers. It acts as an "off" switch when bound to CD80 or CD86 on the surface of antigen-presenting cells.
Product Category	Recombinant Protein / Antibody discovery / Immune checkpoint proteins, ADC targets

Mouse CTLA-4/CD152 Protein (CTL-MM141) Specifications/Details

Protein	CTLA-4/CD152
Synonyms	CTLA4; CD152; ICOS; CELIAC3; GRD4; GSE; ALPS5; IDDM12
Accession	P09793
Species	Mouse
Biotinylated	no
Amino Acid Range	Glu36-Asp161
Molecular Weight	The protein has a predicted MW of 15.47 kDa. Due to glycosylation, the protein migrates to 28-38 kDa based on Bis-Tris PAGE result.
Activity	Immobilized Mouse CTLA-4, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Human B7-1, hFc Tag (Cat. B71-HM280) with the EC50 of 1.9ng/ml determined by ELISA.
Product Tag	C-His
Fluorophore	Unconjugated
Expression System	HEK293
Purity	> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin	Less than 0.1 EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking.
Stability And Storage	-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

	Immobilized Mouse CTLA-4, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Human B7-1, hFc Tag (Cat. B71-HM280) with the EC50 of 1.9ng/ml determined by ELISA.
	Mouse CTLA-4 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
	The purity of Mouse CTLA-4 is greater than 95% as determined by SEC-HPLC.

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