Mouse EPHA4 Protein (EPH-MM104)
Mouse EPHA4 Protein (EPH-MM104)
  • Express System: HEK293
  • Product Tag: C-His
  • Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
  • Amino Acid Range: Val20-Thr547
Catalog #EPH-MM104
Regular price $270.00
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Product Description
Recombinant Mouse EPHA4 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Val20-Thr547.
Product Background
The expression and activation of EphA4 in the various cell types in a knee joint was upregulated upon an intraarticular injury. To determine if EphA4 signaling plays a role in osteoarthritis, we determined whether deficient EphA4 expression (in EphA4 knockout mice) or upregulation of the EphA4 signaling (with the EfnA4-fc treatment) would alter cellular functions of synoviocytes and articular chondrocytes. In synoviocytes, deficient EphA4 expression enhanced, whereas activation of the EphA4 signaling reduced, expression and secretion of key inflammatory cytokines and matrix metalloproteases.
Product Category
Recombinant Protein
Target
EPHA4
Synonyms
Sek; Sek1; EphA4; HEK8; SEK; TYRO1; EK8
Accession
Species
Mouse
Biotinylated
no
Amino Acid Range
Val20-Thr547
Molecular Weight
The protein has a predicted MW of 59.4 kDa. Due to glycosylation, the protein migrates to 60-70 kDa based on Bis-Tris PAGE result.
Product Tag
C-His
Express System
HEK293
Purity
> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin
Less than 1EU per ug by the LAL method.
Form
Lyophilized
Shipping
Shipped at ambient temperature.
Formulation
Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage
Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Mouse EPHA4 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
The purity of Mouse EPHA4 is greater than 95% as determined by SEC-HPLC.

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