Product Description |
Recombinant Mouse Factor H/CFH Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Ser875-Val1252. |
Product Background |
Factor H is the major soluble inhibitor of complement, where its binding to self markers (i.e., particular glycan structures) prevents complement activation and amplification on host surfaces. Not surprisingly, mutations and polymorphisms that affect recognition of self by factor H are associated with diseases of complement dysregulation, such as age-related macular degeneration and atypical haemolytic uremic syndrome. In addition, pathogens (i.e., non-self) and cancer cells (i.e., altered-self) can hijack factor H to evade the immune response. |
Product Category |
Recombinant Protein / Antibody discovery / Antibody discovery | Others |
Protein |
Factor H/CFH |
Synonyms |
Complement factor H; H factor 1; CFH; HF; HF1; HF2; AHUS1; AMBP1; ARMD4; ARMS1; CFHL3; FH; FHL1; HUS |
Accession |
|
Species |
Mouse |
Biotinylated |
no |
Amino Acid Range |
Ser875-Val1252 |
Molecular Weight |
The protein has a predicted MW of 42.5 kDa. Due to glycosylation, the protein migrates to 60-65 kDa based on Bis-Tris PAGE result. |
Product Tag |
C-His |
Expression System |
HEK293 |
Purity |
> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC |
Endotoxin |
Less than 1 EU per ug by the LAL method. |
Form |
Lyophilized |
Shipping |
Shipped at ambient temperature. |
Formulation |
Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution |
Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking. |
Stability And Storage |
-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
|
|
Mouse Factor H/CFH on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
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The purity of Mouse Factor H/CFH is greater than 95% as determined by SEC-HPLC. |
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