Product Description |
Recombinant Mouse FAM3D Protein is expressed from HEK293 with hFc tag at the C-Terminus.It contains Tyr26-Met223. |
Product Background |
The physiological homeostasis of gut mucosal barrier is maintained by both genetic and environmental factors and its impairment leads to pathogenesis such as inflammatory bowel disease. A cytokine like molecule, FAM3D (mouse Fam3D), is highly expressed in mouse gastrointestinal tract. Here, we demonstrate that deficiency in Fam3D is associated with impaired integrity of colonic mucosa, increased epithelial hyper-proliferation, reduced anti-microbial peptide production and increased sensitivity to chemically induced colitis associated with high incidence of cancer. |
Product Category |
Recombinant Protein |
Target |
FAM3D |
Synonyms |
EF7; FAM3D; OIT1 |
Accession |
|
Species |
Mouse |
Biotinylated |
no |
Amino Acid Range |
Tyr26-Met223 |
Molecular Weight |
The protein has a predicted MW of 48.7 kDa. Due to glycosylation, the protein migrates to 52-58 kDa based on Bis-Tris PAGE result. |
Product Tag |
C-hFc |
Express System |
HEK293 |
Purity |
> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC |
Endotoxin |
Less than 1EU per ug by the LAL method. |
Form |
Lyophilized |
Shipping |
Shipped at ambient temperature. |
Formulation |
Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution |
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
Stability And Storage |
Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
|
|
Mouse FAM3D on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
|
|
The purity of Mouse FAM3D is greater than 95% as determined by SEC-HPLC. |
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