Mouse Fas/TNFRSF6/CD95 Protein (FAS-MM201)

  • Express System: HEK293
  • Product Tag: C-hFc
  • Purity: > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
  • Activity: Immobilized Human Fas Ligand, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Mouse Fas, hFc Tag with the EC50 of 0.25ug/ml determined by ELISA. See testing image for detail.
  • Amino Acid Range: Gln22-Arg169

Catalog: FAS-MM201

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Product Description Recombinant Mouse Fas/TNFRSF6/CD95 Protein is expressed from HEK293 with hFc tag at the C-Terminus.It contains Gln22-Arg169.

Product Background

CD95 (also known as Fas) is a member of the tumor necrosis factor receptor (TNFR) superfamily. Its cognate ligand, CD95L, is implicated in immune homeostasis and immune surveillance. Mutations in this receptor are associated with a loss of apoptotic signaling and have been detected in an autoimmune disorder called autoimmune lymphoproliferative syndrome (ALPS) type Ia, which shares some clinical features with systemic lupus erythematosus (SLE).

Product Category

Recombinant Protein

Target

Fas/TNFRSF6/CD95
Synonyms FASLG receptor; CD95; APT1; FAS1; TNFRSF6; FAS; ALPS1A; APO1; FASTM; FasR
Accession

Species

Mouse

Amino Acid Range

Gln22-Arg169
Molecular Weight The protein has a predicted MW of 43.3 kDa. Due to glycosylation, the protein migrates to 60-65 kDa based on Tris-Bis PAGE result.

Activity

Immobilized Human Fas Ligand, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Mouse Fas, hFc Tag with the EC50 of 0.25ug/ml determined by ELISA. See testing image for detail.

Product Tag

C-hFc

Express System

HEK293
Purity > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
Endotoxin Less than 1EU per ug by the LAL method.
Form Lyophilized
Shipping Shipped at ambient temperature.
Formulation Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Immobilized Human Fas Ligand, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Mouse Fas, hFc Tag with the EC50 of 0.25ug/ml determined by ELISA.
The purity of Mouse Fas is greater than 95% as determined by SEC-HPLC.
Mouse Fas on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

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