Mouse GARP&Latent TGF beta 1 Complex Protein (GAT-MM101) Summary
Product Description |
Recombinant Mouse GARP&Latent TGF beta 1 Complex Protein is expressed from HEK293 with His tag at the N-Terminus of Latent TGF beta 1.It contains Ala18-Leu628(GARP) and Leu30-Ser390(Latent TGF beta 1). |
Product Background |
GARP&Latent TGF Beta is a complex found on surface of many types of cells. In Tregs, GARP is involved in TCR-mediated activation of Latent TGF-β and thus promoting secretion and activation of TGF-β. Integrin αvβ8 on the surface of immune cells and other cells recognizes RGD in LAP, resulting in the release of mature TGF-β from the TGF-β&GARP complex. |
Product Category |
Recombinant Protein / Antibody discovery / Antibody discovery | Others |
Mouse GARP&Latent TGF beta 1 Complex Protein (GAT-MM101) Specifications/Details
Protein |
GARP&Latent TGF beta 1 Complex |
Synonyms |
LRRC32; GARP; LAP; TGF-beta-1; LRRC32&TGF-beta 1; LRRC32&TGFB1; TGF-β-1; LRRC32&TGF-β 1; GARP&Latent TGF Beta; GARP&Latent TGF Beta 1 |
Accession |
|
Species |
Mouse |
Biotinylated |
no |
Amino Acid Range |
Ala18-Leu628(GARP) & Leu30-Ser390(Latent TGF beta 1) |
Molecular Weight |
The protein has a predicted MW of 66.6 kDa (GARP)&41.3 kDa (Latent TGF beta 1). Due to glycosylation, the protein migrates to 70-80 kDa (GARP)&13 kDa&42-50 kDa (Latent TGF beta 1) based on Bis-Tris PAGE result. |
Product Tag |
N-His |
Expression System |
HEK293 |
Purity |
> 95% as determined by Bis-Tris PAGE;> 90% as determined by HPLC |
Endotoxin |
Less than 1 EU per ug by the LAL method. |
Form |
Lyophilized |
Shipping |
Shipped at ambient temperature. |
Formulation |
Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution |
Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking. |
Stability And Storage |
-20 to -80°C for 12 months as supplied from date of receipt.;-80°C for 3 months after reconstitution.;Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
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