Product Description |
Recombinant Mouse GITR Ligand/TNFSF18 Protein is expressed from HEK293 with hFc tag at the N-Terminus.It contains Thr47-Ser173. |
Product Background |
Glucocorticoid-induced TNFR-related protein (TNFRSF18, GITR, CD357), expressed by T cells, and its ligand (TNFSF18, GITRL), expressed by myeloid populations, provide co-stimulatory signals that boost T cell activity. Due to the important role that GITR plays in regulating immune functions, agonistic stimulation of GITR is a promising therapeutic concept. |
Product Category |
Recombinant Protein |
Target |
GITR Ligand/TNFSF18 |
Synonyms |
TNFSF18; AITRL; TL6; GITRL; GITR Ligand |
Accession |
|
Species |
Mouse |
Biotinylated |
no |
Amino Acid Range |
Thr47-Ser173 |
Molecular Weight |
The protein has a predicted MW of 41.8 kDa. Due to glycosylation, the protein migrates to 50-60 kDa based on Bis-Tris PAGE result. |
Product Tag |
N-hFc |
Express System |
HEK293 |
Purity |
> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC |
Endotoxin |
Less than 1EU per ug by the LAL method. |
Form |
Lyophilized |
Shipping |
Shipped at ambient temperature. |
Formulation |
Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution |
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
Stability And Storage |
Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
|
|
Mouse GITR Ligand on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
|
|
The purity of Mouse GITR Ligand is greater than 95% as determined by SEC-HPLC. |
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