Product Description |
Recombinant Mouse Hepcidin/HAMP Protein is expressed from E.coli with GST tag at the N-Terminus.It contains Asp59-Thr83. |
Product Background |
Hepcidin, the main regulator of iron metabolism, is synthesized and released by hepatocytes in response to increased body iron concentration and inflammation. Deregulation of hepcidin expression is a common feature of genetic and acquired iron disorders: in Hereditary Hemochromatosis (HH) and iron-loading anemias low hepcidin causes iron overload, while in Iron Refractory Iron Deficiency Anemia (IRIDA) and anemia of inflammation (AI), high hepcidin levels induce iron-restricted erythropoiesis. |
Product Category |
Recombinant Protein / Antibody discovery |
Protein |
Hepcidin/HAMP |
Synonyms |
Hamp1; Hepc; Hepc1; HFE2B; LEAP1; LEAP-1; PLTR |
Accession |
|
Species |
Mouse |
Biotinylated |
no |
Amino Acid Range |
Asp59-Thr83 |
Molecular Weight |
The protein has a predicted MW of 29.05 kDa same as Bis-Tris PAGE result. |
Product Tag |
N-GST |
Expression System |
E.coli |
Purity |
> 95% as determined by Bis-Tris PAGE |
Endotoxin |
Less than 1EU per ug by the LAL method. |
Form |
Lyophilized |
Shipping |
Shipped at ambient temperature. |
Formulation |
Lyophilized from 0.22um filtered solution in 50mM Tris-HCl, 150mM NaCl, 2mM DTT (pH 7.5). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution |
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
Stability And Storage |
-20 to -80°C for 12 months as supplied from date of receipt.;-80°C for 3 months after reconstitution.;Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
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