Mouse IGFBP-3R Protein (IGF-MM23R) Summary
Product Description |
Recombinant Mouse IGFBP-3R Protein is expressed from HEK293 with hFc tag at the C-Terminus.It contains Gly39-Arg204. |
Product Background |
Insulin-like growth factor-binding protein-3 (IGFBP-3) is a multifunctional protein known for modulating mitogenic and metabolic actions of IGFs as well as exerting a variety of biological actions not involving IGF. IGFBP-3 inhibits airway inflammation and hyper-responsiveness via an IGF-independent mechanism that involves activation of IGFBP-3R signaling and cross-talk with NF-κB signaling. The IGFBP-3/IGFBP-3R system therefore plays a pivotal role in the pathogenesis of asthma and can serve as a newly identified potential therapeutic target for this debilitating disease. |
Product Category |
Recombinant Protein / Antibody discovery / Antibody discovery | Others |
Mouse IGFBP-3R Protein (IGF-MM23R) Specifications/Details
Protein |
IGFBP-3R |
Synonyms |
IGFBP-3R; GFBP3R; LOC124446; TMEM219 |
Accession |
|
Species |
Mouse |
Biotinylated |
no |
Amino Acid Range |
Gly39-Arg204 |
Molecular Weight |
The protein has a predicted MW of 44.4 kDa. Due to glycosylation, the protein migrates to 60-70 kDa based on Bis-Tris PAGE result. |
Product Tag |
C-hFc |
Expression System |
HEK293 |
Purity |
> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC |
Endotoxin |
Less than 1 EU per ug by the LAL method. |
Shipping, Reconstitution, & Storage
Form |
Lyophilized |
Shipping |
Shipped at ambient temperature. |
Formulation |
Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution |
Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking. |
Stability And Storage |
-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
Validation Images
|
|
Mouse IGFBP-3R on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
|
|
The purity of Mouse IGFBP-3R is greater than 95% as determined by SEC-HPLC. |
Related Products
Have more questions?
Check out our Frequently Asked Questions page for more details about product specifications, ordering, and shipments.
Contact Us
More from Antibody Drug Discovery Proteins
Recently viewed
