Mouse IGFBP-7 Protein (IGF-MM2BP)

Express System: HEK293
Product Tag: C-hFc
Purity: > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
Activity: The affinity constant of 0.59 uM as determined in SPR assay (Biacore T200). See testing image for detail.
Exact Sequence: Ser26-Leu281

Catalog: IGF-MM2BP

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Product Description	Recombinant Mouse IGFBP-7 Protein is expressed from HEK293 with hFc tag at the C-terminus.It contains Ser26-Leu281.
Product Background	IGFBP-7, also known as Mac25/Angiomodulin (AGM), GFBP-rp1, tumor-derived adhesion factor (TAF) and prostacyclin-stimulating factor (PSF), is a secreted protein that contains three protein domain modules. Human IGFBP-rp1 cDNA encodes 282 amino acid (aa) residue precursor protein with a putative 26 aa signal peptide. IGFBP-7 binds IGF-I and IGF-II with a relatively low affinity. Stimulates prostacyclin (PGI2) production. Stimulates cell adhesion.
Product Category	Recombinant Protein

Target	IGFBP-7
Gene/Protein ID	Q61581
Species	Mouse
Exact Sequence	Ser26-Leu281
Molecular Weight	The protein has a predicted MW of 53.03 kDa. Due to glycosylation, the protein migrates to 55-70 kDa based on Tris-Bis PAGE result.
Activity	The affinity constant of 0.59 uM as determined in SPR assay (Biacore T200). See testing image for detail.
Product Tag	C-hFc
Express System	HEK293
Purity	> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
Endotoxin	Less than 1EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage	Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

	Mouse IGFBP-7, hFc Tag captured on CM5 Chip via Protein A can bind Human CD93, His Tag with an affinity constant of 0.59 uM as determined in SPR assay (Biacore T200).
	The purity of Mouse IGFBP-7 is greater than 95% as determined by SEC-HPLC.
	Mouse IGFBP-7 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.