Product Description |
Recombinant Mouse IGFBP-7 Protein is expressed from HEK293 with hFc tag at the C-terminus.It contains Ser26-Leu281. |
Product Background |
IGFBP-7, also known as Mac25/Angiomodulin (AGM), GFBP-rp1, tumor-derived adhesion factor (TAF) and prostacyclin-stimulating factor (PSF), is a secreted protein that contains three protein domain modules. Human IGFBP-rp1 cDNA encodes 282 amino acid (aa) residue precursor protein with a putative 26 aa signal peptide. IGFBP-7 binds IGF-I and IGF-II with a relatively low affinity. Stimulates prostacyclin (PGI2) production. Stimulates cell adhesion. |
Product Category |
Recombinant Protein |
Target |
IGFBP-7 |
Synonyms |
IGFBP-7; IBP7; AGM; FSTL2; IGFBP-7v; IGFBPRP1; MAC25; PSF; RAMSVPS; TAF |
Accession |
|
Species |
Mouse |
Biotinylated |
no |
Amino Acid Range |
Ser26-Leu281 |
Molecular Weight |
The protein has a predicted MW of 53.03 kDa. Due to glycosylation, the protein migrates to 55-70 kDa based on Bis-Tris PAGE result. |
Activity |
The affinity constant of 0.59 uM as determined in SPR assay (Biacore T200). See testing image for detail. |
Product Tag |
C-hFc |
Express System |
HEK293 |
Purity |
> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC |
Endotoxin |
Less than 1EU per ug by the LAL method. |
Form |
Lyophilized |
Shipping |
Shipped at ambient temperature. |
Formulation |
Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution |
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
Stability And Storage |
Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
|
|
Mouse IGFBP-7, hFc Tag captured on CM5 Chip via Protein A can bind Human CD93, His Tag with an affinity constant of 0.59 uM as determined in SPR assay (Biacore T200). |
|
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Mouse IGFBP-7 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
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The purity of Mouse IGFBP-7 is greater than 95% as determined by SEC-HPLC. |
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