Name: Mouse IL-18BP Protein (IL8-MM1BP)
Brand: KactusBio
SKU: IL8-MM1BP-100UG
Price: 120.0 USD
Availability: InStock

Express System: HEK293
Product Tag: C-His
Purity: > 95% as determined by Bis-Tris PAGE
Activity: Immobilized Mouse IL-18BP, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated IL-18, No Tag with the EC50 of 21.5ng/ml determined by ELISA (QC Test). The affinity constant of 0.86 nM as determined in SPR assay (Biacore T200). See testing image for detail.
Amino Acid Range: Thr29-Ala193

Catalog #IL8-MM1BP

Size

100UG

500UG

Order now, ships by:

Product Description	Recombinant Mouse IL-18BP Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Thr29-Ala193.
Product Background	Cytokines were the first modern immunotherapies to produce durable responses in patients with advanced cancer,components of the interleukin-18 (IL-18) pathway are upregulated on tumour-infiltrating lymphocytes, suggesting that IL-18 therapy could enhance anti-tumour immunity. IL-18BP, a high-affinity IL-18 decoy receptor, is frequently upregulated in diverse human and mouse tumours and limits the anti-tumour activity of IL-18 in mice.
Product Category	Recombinant Protein

Protein	IL-18BP
Synonyms	IL-18BP; Igifbp
Accession	Q9Z0M9
Species	Mouse
Biotinylated	no
Amino Acid Range	Thr29-Ala193
Molecular Weight	The protein has a predicted MW of 19.1 kDa. Due to glycosylation, the protein migrates to 45-65 kDa based on Bis-Tris PAGE result.
Activity	Immobilized Mouse IL-18BP, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated IL-18, No Tag with the EC50 of 21.5ng/ml determined by ELISA (QC Test). The affinity constant of 0.86 nM as determined in SPR assay (Biacore T200). See testing image for detail.
Product Tag	C-His
Expression System	HEK293
Purity	> 95% as determined by Bis-Tris PAGE
Endotoxin	Less than 1EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage	Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

	Mouse IL-18BP, His Tag captured on CM5 Chip via anti-his antibody can bind Human IL-18, No Tag with an affinity constant of 0.86 nM as determined in SPR assay (Biacore T200).
	Immobilized Mouse IL-18BP, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated IL-18, No Tag with the EC50 of 21.5ng/ml determined by ELISA (QC Test).
	Mouse IL-18BP on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

Check out our Frequently Asked Questions page for more details about product specifications, ordering, and shipments.

Product Description

Product Background