Mouse IL-18BP Protein (IL8-MM2BP)
Mouse IL-18BP Protein (IL8-MM2BP)
  • Express System: HEK293
  • Product Tag: C-hFc
  • Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
  • Activity: Immobilized Mouse IL-18BP, hFc Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Human IL-18, No Tag with the EC50 of 8.2ng/ml determined by ELISA. See testing image for detail.
  • Amino Acid Range: Thr29-Ala193
Catalog #IL8-MM2BP
Regular price $270.00
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Product Description
Recombinant Mouse IL-18BP Protein is expressed from HEK293 with hFc tag at the C-Terminus.It contains Thr29-Ala193.
Product Background
Cytokines were the first modern immunotherapies to produce durable responses in patients with advanced cancer,components of the interleukin-18 (IL-18) pathway are upregulated on tumour-infiltrating lymphocytes, suggesting that IL-18 therapy could enhance anti-tumour immunity. IL-18BP, a high-affinity IL-18 decoy receptor, is frequently upregulated in diverse human and mouse tumours and limits the anti-tumour activity of IL-18 in mice.
Product Category
Recombinant Protein
Target
IL-18BP
Synonyms
IL-18BP; Igifbp
Accession
Species
Mouse
Biotinylated
no
Amino Acid Range
Thr29-Ala193
Molecular Weight
The protein has a predicted MW of 44.7 kDa. Due to glycosylation, the protein migrates to 60-75 kDa based on Bis-Tris PAGE result.
Activity
Immobilized Mouse IL-18BP, hFc Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Human IL-18, No Tag with the EC50 of 8.2ng/ml determined by ELISA. See testing image for detail.
Product Tag
C-hFc
Express System
HEK293
Purity
> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin
Less than 1EU per ug by the LAL method.
Form
Lyophilized
Shipping
Shipped at ambient temperature.
Formulation
Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage
Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Immobilized Mouse IL-18BP, hFc Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Human IL-18, No Tag with the EC50 of 8.2ng/ml determined by ELISA.
Mouse IL-18BP on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
The purity of Mouse IL-18BP is greater than 95% as determined by SEC-HPLC.

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