Name: Mouse IL-18BP Protein (IL8-MM2BP)
Brand: KactusBio
SKU: IL8-MM2BP-100UG
Price: 297.0 USD
Availability: InStock

Express System: HEK293
Product Tag: C-hFc
Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Activity: Immobilized Mouse IL-18BP, hFc Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Human IL-18, No Tag with the EC50 of 8.2ng/ml determined by ELISA. See testing image for detail.
Amino Acid Range: Thr29-Ala193

Catalog #IL8-MM2BP

Size

100UG

500UG

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Mouse IL-18BP Protein (IL8-MM2BP) Summary

Product Description	Recombinant Mouse IL-18BP Protein is expressed from HEK293 with hFc tag at the C-Terminus.It contains Thr29-Ala193.
Product Background	Cytokines were the first modern immunotherapies to produce durable responses in patients with advanced cancer,components of the interleukin-18 (IL-18) pathway are upregulated on tumour-infiltrating lymphocytes, suggesting that IL-18 therapy could enhance anti-tumour immunity. IL-18BP, a high-affinity IL-18 decoy receptor, is frequently upregulated in diverse human and mouse tumours and limits the anti-tumour activity of IL-18 in mice.
Product Category	Recombinant Protein / Antibody discovery / Antibody discovery \| Others

Mouse IL-18BP Protein (IL8-MM2BP) Specifications/Details

Protein	IL-18BP
Synonyms	IL-18BP; Igifbp
Accession	Q9Z0M9
Species	Mouse
Biotinylated	no
Amino Acid Range	Thr29-Ala193
Molecular Weight	The protein has a predicted MW of 44.7 kDa. Due to glycosylation, the protein migrates to 60-75 kDa based on Bis-Tris PAGE result.
Activity	Immobilized Mouse IL-18BP, hFc Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Human IL-18, No Tag with the EC50 of 8.2ng/ml determined by ELISA. See testing image for detail.
Product Tag	C-hFc
Expression System	HEK293
Purity	> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin	Less than 1 EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking.
Stability And Storage	-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

	Immobilized Mouse IL-18BP, hFc Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Human IL-18, No Tag with the EC50 of 8.2ng/ml determined by ELISA.
	Mouse IL-18BP on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
	The purity of Mouse IL-18BP is greater than 95% as determined by SEC-HPLC.