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Mouse IL-21R Protein, Ultra Low Endotoxin (ILR-MM121-UL) Summary
Product Description |
Recombinant Mouse IL-21R Protein is expressed from HEK293 with His tag at the C-terminus.It contains Cys20-His237. |
Product Background |
IL-21 and IL-21R were highly expressed in the lesional skin and peripheral blood of psoriasis patients. IL-21 promoted CD4 T cells proliferation and Th17 cells differentiation and inhibiting Treg cells differentiation by upregulating RORγt expression and downregulating Foxp3 expression, with increased expression and secretion of IL-17A and IL-22.Microbial translocation and the associated immune activation during HIV-1 infection may lead to high expression levels of the IL-21R activation marker in RM B cells, a feature associated with increased apoptosis and a reduced number of these cells in the circulation. |
Product Category |
Recombinant Protein / Antibody discovery / Antibody discovery/Others |
Mouse IL-21R Protein, Ultra Low Endotoxin (ILR-MM121-UL) Specifications/Details
Protein |
IL-21R |
Synonyms |
IL-21 receptor; IL21R; CD360; NILR |
Accession |
|
Species |
Mouse |
Biotinylated |
no |
Amino Acid Range |
Cys20-His237 |
Molecular Weight |
The protein has a predicted MW of 26.64 kDa. Due to glycosylation, the protein migrates to 38-52 kDa based on Bis-Tris PAGE result. |
Activity |
Immobilized Mouse IL-21R, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Mouse IL-21, His Avi Tag with the EC50 of 4.1ng/ml determined by ELISA. |
Product Tag |
C-His |
Fluorophore |
Unconjugated |
Expression System |
HEK293 |
Purity |
> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC |
Endotoxin |
Less than 0.01 EU per ug by the LAL method. |
Shipping, Reconstitution, & Storage
Form |
Lyophilized |
Shipping |
Shipped at ambient temperature. |
Formulation |
Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution |
Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking. |
Stability And Storage |
-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
Validation Images
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Immobilized Mouse IL-21R, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Mouse IL-21, His Avi Tag with the EC50 of 4.1ng/ml determined by ELISA. |
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Mouse IL-21R on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
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The purity of Mouse IL-21R is greater than 95% as determined by SEC-HPLC. |
Other Available Proteins:
Finding available proteins...
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