Name: Mouse Integrin alpha 1 beta 1 (ITGA1&ITGB1) Heterodimer Protein (ITG-MM1A1)
Brand: KactusBio
SKU: ITG-MM1A1-100UG
Price: 375.0 USD
Availability: InStock

Mouse Integrin alpha 1 beta 1 (ITGA1&ITGB1) Heterodimer Protein (ITG-MM1A1)

Express System: HEK293
Product Tag: C-His
Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Amino Acid Range: Phe29-Pro1141(ITGA1)acidic tail & Gln21-Asp728(ITGB1)basic tail

Catalog #ITG-MM1A1

Size

100UG

500UG

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Product Description	Recombinant Mouse Integrin alpha 1 beta 1 (ITGA1&ITGB1) Heterodimer Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Phe29-Pro1141(ITGA1) acidic tail&Gln21-Asp728(ITGB1) basic tail.
Product Background	Integrin α1β1 is a heterodimer of the Integrin subunits alpha 1 and beta 1 and is one of four collagen‑binding integrins, it preferentially binds Collagens I, IV, VI, XIII and XVI, but also binds Laminin. Integrin α1β1 is widely expressed in mesenchyme and the immune system, as well as a minority of epithelial tissues. It can suppresse EGFR signaling, increase expression of Caveolin-1, reduce production of reactive oxygen species, regulate collagen expression, regulate MMP collagenase and gelatinase activity, and mediates the renal basement membrane disorder Alport syndrome.
Product Category	Recombinant Protein

Target	Integrin alpha 1 beta 1 (ITGA1&ITGB1) Heterodimer
Accession	Q3V3R4(ITGA1)&P09055-1(ITGB1)
Species	Mouse
Biotinylated	no
Amino Acid Range	Phe29-Pro1141(ITGA1)acidic tail & Gln21-Asp728(ITGB1)basic tail
Molecular Weight	The protein has a predicted MW of 129.00 kDa (ITGA1)&82.80 kDa (ITGB1). Due to glycosylation, the protein migrates to 140-200 kDa (ITGA1) and 100-115 kDa (ITGB1) based on Bis-Tris PAGE result.
Product Tag	C-His
Express System	HEK293
Purity	> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin	Less than 1EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage	Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

	Mouse ITGA1&ITGB1 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
	The purity of Mouse ITGA1&ITGB1 is greater than 95% as determined by SEC-HPLC.

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