Product Description |
Recombinant Mouse Integrin alpha L beta 2 (ITGAL&ITGB2) Heterodimer Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Tyr24-His1087 (ITGAL) acidic tail & Gln24-Asn702 (ITGB2) basic tail. |
Product Background |
Integrin αLβ2 is one member of the integrin family and also called leukocyte function-associated antigen-1 (LFA-1). It is widely expressed on T lymphocytes and controls the function and, in particular, the migration of immune cells[1]. Active αLβ2 can bind ICAM1/CD54, ICAM2, ICAM3 and JAM1[2]. |
Product Category |
Recombinant Protein |
Target |
Integrin alpha L beta 2 (ITGAL&ITGB2) Heterodimer |
Synonyms |
αLβ2; ITGAL&ITGB2; ITGAL; ITGB2 |
Accession |
|
Species |
Mouse |
Biotinylated |
no |
Amino Acid Range |
Tyr24-His1087 (ITGAL) acidic tail & Gln24-Asn702 (ITGB2) basic tail |
Molecular Weight |
The protein has a predicted MW of 123.30 kDa (ITGAL) and 79.60 kDa (ITGB2). Due to glycosylation, the protein migrates to 160-180 kDa (ITGAL) and 90-105 kDa (ITGB2) based on Bis-Tris PAGE result. |
Product Tag |
C-His |
Express System |
HEK293 |
Purity |
> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC |
Endotoxin |
Less than 1EU per ug by the LAL method. |
Form |
Lyophilized |
Shipping |
Shipped at ambient temperature. |
Formulation |
Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution |
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
Stability And Storage |
Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
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