Product Description |
Recombinant Mouse Integrin alpha V beta 8 (ITGAV&ITGB8) Heterodimer Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Phe31-Val988(ITGAV) acidic tail & Gly22-Ser679(ITGB8) basic tail. |
Product Background |
Deletions of the genes encoding the integrin αVβ8 (Itgav, Itgb8) have been shown to result in abnormal vascular development in the CNS, including prenatal and perinatal hemorrhage. Other work has indicated that a major function of this integrin in vivo is to promote TGFβ activation. |
Product Category |
Recombinant Protein |
Target |
Integrin alpha V beta 8 (ITGAV&ITGB8) Heterodimer |
Synonyms |
αVβ8; Integrin alpha V beta 8;ITGAV&ITGB8;Integrin alpha V β 8 |
Accession |
|
Species |
Mouse |
Biotinylated |
no |
Amino Acid Range |
Phe31-Val988(ITGAV) acidic tail & Gly22-Ser679(ITGB8) basic tail |
Molecular Weight |
The protein has a predicted MW of 111.6(ITGAV) & 76.6(ITGB8) kDa. Due to glycosylation, the protein migrates to 80-140 kDa based on Bis-Tris PAGE result. |
Activity |
Immobilized Mouse ITGAV&ITGB8, His Tag at 5ug/ml (100ul/Well) on the plate. Dose response curve for Biotinylated Human Latent TGF beta 1, His Tag with the EC50 of 0.97ug/ml determined by ELISA. See testing image for detail. |
Product Tag |
C-His |
Express System |
HEK293 |
Purity |
> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC |
Endotoxin |
Less than 1EU per ug by the LAL method. |
Form |
Lyophilized |
Shipping |
Shipped at ambient temperature. |
Formulation |
Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution |
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
Stability And Storage |
Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
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Immobilized Mouse ITGAV&ITGB8, His Tag at 5ug/ml (100ul/Well) on the plate. Dose response curve for Biotinylated Human Latent TGF beta 1, His Tag with the EC50 of 0.97ug/ml determined by ELISA. |
|
|
Mouse ITGAV&ITGB8 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
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The purity of Mouse ITGAV&ITGB8 is greater than 95% as determined by SEC-HPLC. |
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