Mouse Integrin alpha V beta 8 (ITGAV&ITGB8) Heterodimer Protein (ITG-MM1V8)
Mouse Integrin alpha V beta 8 (ITGAV&ITGB8) Heterodimer Protein (ITG-MM1V8)
  • Express System: HEK293
  • Product Tag: C-His
  • Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
  • Activity: Immobilized Mouse ITGAV&ITGB8, His Tag at 5ug/ml (100ul/Well) on the plate. Dose response curve for Biotinylated Human Latent TGF beta 1, His Tag with the EC50 of 0.97ug/ml determined by ELISA. See testing image for detail.
  • Amino Acid Range: Phe31-Val988(ITGAV) acidic tail & Gly22-Ser679(ITGB8) basic tail
Catalog #ITG-MM1V8
Regular price $330.00
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Product Description
Recombinant Mouse Integrin alpha V beta 8 (ITGAV&ITGB8) Heterodimer Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Phe31-Val988(ITGAV) acidic tail & Gly22-Ser679(ITGB8) basic tail.
Product Background
Deletions of the genes encoding the integrin αVβ8 (Itgav, Itgb8) have been shown to result in abnormal vascular development in the CNS, including prenatal and perinatal hemorrhage. Other work has indicated that a major function of this integrin in vivo is to promote TGFβ activation.
Product Category
Recombinant Protein
Target
Integrin alpha V beta 8 (ITGAV&ITGB8) Heterodimer
Synonyms
Integrin alpha V beta 8;ITGAV&ITGB8
Accession
Species
Mouse
Biotinylated
no
Amino Acid Range
Phe31-Val988(ITGAV) acidic tail & Gly22-Ser679(ITGB8) basic tail
Molecular Weight
The protein has a predicted MW of 111.6(ITGAV) & 76.6(ITGB8) kDa. Due to glycosylation, the protein migrates to 80-140 kDa based on Bis-Tris PAGE result.
Activity
Immobilized Mouse ITGAV&ITGB8, His Tag at 5ug/ml (100ul/Well) on the plate. Dose response curve for Biotinylated Human Latent TGF beta 1, His Tag with the EC50 of 0.97ug/ml determined by ELISA. See testing image for detail.
Product Tag
C-His
Express System
HEK293
Purity
> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin
Less than 1EU per ug by the LAL method.
Form
Lyophilized
Shipping
Shipped at ambient temperature.
Formulation
Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage
Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Immobilized Mouse ITGAV&ITGB8, His Tag at 5ug/ml (100ul/Well) on the plate. Dose response curve for Biotinylated Human Latent TGF beta 1, His Tag with the EC50 of 0.97ug/ml determined by ELISA.
Mouse ITGAV&ITGB8 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
The purity of Mouse ITGAV&ITGB8 is greater than 95% as determined by SEC-HPLC.

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