Mouse Kallikrein 5/KLK5 Protein (KLK-MM105)
Mouse Kallikrein 5/KLK5 Protein (KLK-MM105)
  • Express System: HEK293
  • Product Tag: C-His
  • Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
  • Amino Acid Range: Gly30-Asn293
Catalog #KLK-MM105
Regular price $297.00
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Product Description

Recombinant Mouse Kallikrein 5/KLK5 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Gly30-Asn293.

Product Background

The inhibition of kallikrein 5 (KLK5) has been identified as a potential strategy for treatment of the genetic skin disorder Netherton syndrome, in which loss-of-function mutations in the SPINK5 gene lead to down-regulation of the endogenous inhibitor LEKTI-1 and profound skin-barrier defects with severe allergic manifestations. To aid in the development of a medicine for this target, an X-ray crystallographic system was developed to facilitate fragment-guided chemistry and knowledge-based drug-discovery approaches.

Product Category

Recombinant Protein / Antibody discovery

Protein

Kallikrein 5/KLK5

Synonyms

Kallikrein c; Klnc; KLK5; KLKL2; KLK-L2; SCTE

Accession

Species

Mouse

Biotinylated

no

Amino Acid Range

Gly30-Asn293

Molecular Weight

The protein has a predicted MW of 29.9 kDa. Due to glycosylation, the protein migrates to 40-50 kDa based on Bis-Tris PAGE result.

Product Tag

C-His

Expression System

HEK293

Purity

> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC

Endotoxin

Less than 1EU per ug by the LAL method.
Form
Lyophilized
Shipping
Shipped at ambient temperature.
Formulation
Lyophilized from 0.22um filtered solution in 20mM NaAc, 150mM NaCl (pH 5.0). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in 20mM NaAc, 150mM NaCl (pH 5.0).
Stability And Storage
-20 to -80°C for 12 months as supplied from date of receipt.;-80°C for 3 months after reconstitution.;Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Mouse Kallikrein 5 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. Mouse Kallikrein 5 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
The purity of Mouse Kallikrein 5 is greater than 95% as determined by SEC-HPLC. The purity of Mouse Kallikrein 5 is greater than 95% as determined by SEC-HPLC.

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