Mouse KLRG1 Protein (KLR-MM2G1)
Catalog: KLR-MM2G1
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| Product Description | Recombinant Mouse KLRG1 Protein is expressed from HEK293 with hFc tag at the N-Terminus.It contains Gln57-Tyr188. |
Product Background |
Immune homeostasis requires the tight, tissue-specific control of the different CD4 Foxp3 regulatory T (Treg) cell populations. The cadherin-binding inhibitory receptor killer cell lectin-like receptor G1 (KLRG1) is expressed by a subpopulation of Treg cells with GATA3 effector phenotype.Lack of KLRG1 on Treg cells conferred on them a competitive advantage in the gut, but not in lymphoid organs. Hence, although absence of KLRG1 is not enough to increase intestinal Treg cells in KLRG1 knockout mice, KLRG1 ligation reduces T-cell receptor signals and the competitive fitness of individual Treg cells in the intestine. |
Product Category |
Recombinant Protein |
Target |
KLRG1 |
| Synonyms | KLRG1; CLEC15A; MAFA; MAFAL; 2F1; CLEC15AMAFA-LIKE; MGC13600 |
Gene/Protein ID |
O88713 |
Species |
Mouse |
Exact Sequence |
Gln57-Tyr188 |
| Molecular Weight | The protein has a predicted MW of 42.3 kDa. Due to glycosylation, the protein migrates to 50-65 kDa based on Tris-Bis PAGE result. |
Product Tag |
N-hFc |
Express System |
HEK293 |
| Purity | > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC |
| Endotoxin | Less than 1EU per ug by the LAL method. |
| Form | Liquid |
| Shipping | Shipped with dry ice. |
| Formulation | Supplied as 0.22um filtered solution in PBS (pH 7.4). |
| Stability And Storage | Valid for 12 months from date of receipt when stored at -80°C.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
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The purity of Mouse KLRG1 is greater than 95% as determined by SEC-HPLC. |
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Mouse KLRG1 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. |
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