Mouse KLRG1 Protein (KLR-MM2G1)
Mouse KLRG1 Protein (KLR-MM2G1)
Mouse KLRG1 Protein (KLR-MM2G1)
Mouse KLRG1 Protein (KLR-MM2G1)
Mouse KLRG1 Protein (KLR-MM2G1)
Mouse KLRG1 Protein (KLR-MM2G1)
  • Express System: HEK293
  • Product Tag: N-hFc
  • Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
  • Amino Acid Range: Gln57-Tyr188
Catalog #KLR-MM2G1
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Product Description
 Recombinant Mouse KLRG1 Protein is expressed from HEK293 with hFc tag at the N-Terminus.It contains Gln57-Tyr188.
Product Background
 Immune homeostasis requires the tight, tissue-specific control of the different CD4 Foxp3 regulatory T (Treg) cell populations. The cadherin-binding inhibitory receptor killer cell lectin-like receptor G1 (KLRG1) is expressed by a subpopulation of Treg cells with GATA3 effector phenotype.Lack of KLRG1 on Treg cells conferred on them a competitive advantage in the gut, but not in lymphoid organs. Hence, although absence of KLRG1 is not enough to increase intestinal Treg cells in KLRG1 knockout mice, KLRG1 ligation reduces T-cell receptor signals and the competitive fitness of individual Treg cells in the intestine.
Product Category
 Recombinant Protein
Target
 KLRG1
Synonyms
 KLRG1; CLEC15A; MAFA; MAFAL; 2F1; CLEC15AMAFA-LIKE; MGC13600
Accession
Species
 Mouse
Biotinylated
 no
Amino Acid Range
 Gln57-Tyr188
Molecular Weight
 The protein has a predicted MW of 42.3 kDa. Due to glycosylation, the protein migrates to 50-65 kDa based on Bis-Tris PAGE result.
Product Tag
 N-hFc
Express System
 HEK293
Purity
 > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin
 Less than 1EU per ug by the LAL method.
Form
 Lyophilized
Shipping
 Shipped at ambient temperature.
Formulation
 Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution
 Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage
 Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Mouse KLRG1 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
The purity of Mouse KLRG1 is greater than 95% as determined by SEC-HPLC.
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