Product Description |
Recombinant Mouse LAIR1/CD305 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Gln22-Tyr141. |
Product Background |
LAIR1 (leukocyte-associated Ig-like receptor-1, designated CD305) is an approximately 40 kDa type I transmembrane inhibitory glycoprotein belonging to the Ig superfamily.LAIR1 functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. |
Product Category |
Recombinant Protein |
Target |
LAIR1/CD305 |
Synonyms |
CD305; HLAIR1; LAIR1; LAIR-1 |
Accession |
|
Species |
Mouse |
Biotinylated |
no |
Amino Acid Range |
Gln22-Tyr141 |
Molecular Weight |
The protein has a predicted MW of 14.6 kDa. Due to glycosylation, the protein migrates to 30-42 kDa based on Bis-Tris PAGE result. |
Product Tag |
C-His |
Express System |
HEK293 |
Purity |
> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC |
Endotoxin |
Less than 1EU per ug by the LAL method. |
Form |
Lyophilized |
Shipping |
Shipped at ambient temperature. |
Formulation |
Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution |
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
Stability And Storage |
Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
|
|
Mouse LAIR1 on Bis-Tris PAGE under reduced conditions. The purity is greater than 95%. |
|
|
The purity of Mouse LAIR1 is greater than 95% as determined by SEC-HPLC. |
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