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Mouse LTBR Protein (LTB-MM201) Summary
Product Description |
Recombinant Mouse LTBR Protein is expressed from HEK293 with hFc (IgG1) tag at the C-terminus.It contains Gln31-Leu223. |
Product Background |
Components of lymphotoxin beta receptor (LTBR)-associated signaling complexes, including TRAF2, TRAF3, NIK, IKK1, and IKK2 have been shown to participate in the coupling of LTBR to NFkappaB. TRAF3 functions as a negative regulator of LTBR signaling via both canonical and non-canonical NFkappaB pathways by two distinct mechanisms. These effects of TRAF3 depletion did not require LTBR signaling and were consistent with autonomous activation of the non-canonical NFkappaB pathway. |
Product Category |
Recombinant Protein / Antibody discovery / Antibody discovery | Others |
Mouse LTBR Protein (LTB-MM201) Specifications/Details
Protein |
LTBR |
Synonyms |
TNFCR; TNFR3; TNFRSF3; LTBR; CD18; TNFR2-RP; TNFR-RP; LT-BETA-R; TNF-R-III; D12S370; LT-β-R |
Accession |
|
Species |
Mouse |
Biotinylated |
no |
Amino Acid Range |
Gln31-Leu223 |
Molecular Weight |
The protein has a predicted MW of 48.5 kDa. Due to glycosylation, the protein migrates to 55-65 kDa based on Bis-Tris PAGE result. |
Product Tag |
C-hFc (IgG1) |
Fluorophore |
Unconjugated |
Expression System |
HEK293 |
Purity |
> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC |
Endotoxin |
Less than 1 EU per ug by the LAL method. |
Shipping, Reconstitution, & Storage
Form |
Lyophilized |
Shipping |
Shipped at ambient temperature. |
Formulation |
Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution |
Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking. |
Stability And Storage |
-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
Validation Images
|
|
Mouse LTBR on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
|
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The purity of Mouse LTBR is greater than 95% as determined by SEC-HPLC. |
Other Available Proteins:
Finding available proteins...
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