Mouse M-CSF R/CSF1R/CD115 Protein (CSF-MM11R)

  • Express System: HEK293
  • Product Tag: C-His
  • Purity: > 95% as determined by Tris-Bis PAGE
  • Activity: The affinity constant of 1.70 nM as determined in SPR assay (Biacore T200). See testing image for detail.
  • Amino Acid Range: Ala20-Ser511

Catalog: CSF-MM11R

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Product Description Recombinant Mouse M-CSF R/CSF1R/CD115 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Ala20-Ser511.

Product Background

CSF1R also known as M-CSF receptor, the product of the c-fms proto-oncogene, is a member of the type III subfamily of receptor tyrosine kinases that also includes receptors for SCF and PDGF. These receptors each contain five immunoglobulin-like domains in their extracellular domain (ECD) and a split kinase domain in their intracellular region.CSF1R is tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes.

Product Category

Recombinant Protein

Target

M-CSF R/CSF1R/CD115
Synonyms CD115; CSF1R; CSF-1-R; CSFR; FMSFIM2; M-CSF R; MCSFR; M-CSFR; C-FMS; FIM2; FMS; HDLS
Accession

Species

Mouse

Amino Acid Range

Ala20-Ser511
Molecular Weight The protein has a predicted MW of 56.3 kDa. Due to glycosylation, the protein migrates to 76-82 kDa based on Tris-Bis PAGE result.

Activity

The affinity constant of 1.70 nM as determined in SPR assay (Biacore T200). See testing image for detail.

Product Tag

C-His

Express System

HEK293
Purity > 95% as determined by Tris-Bis PAGE
Endotoxin Less than 1EU per ug by the LAL method.
Form Lyophilized
Shipping Shipped at ambient temperature.
Formulation Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Mouse M-CSF R, His tag captured on CM5 Chip via Anti-His Antibody can bind Human M-CSF, No tag with an affinity constant of 1.70 nM as determined in SPR assay (Biacore T200).
Mouse M-CSF R on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

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