Product Description |
Recombinant Mouse P-Selectin/CD62P Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Trp42-Ala709. |
Product Background |
P-selectin is critical in the progression of atherosclerosis as evidenced by knockout animal models where P-selectin knockout mice crossed with apoE deficient mice exhibit significantly reduced atherosclerosis and leukocyte recruitment in the plaque. A soluble form of P-selectin also exists, which may have pro-atherogenic and pro-thrombotic effects. Thus targeting of P-selectin remains a strong clinical candidate for developing novel therapeutic strategies in inflammatory diseases. |
Product Category |
Recombinant Protein |
Target |
P-Selectin/CD62P |
Synonyms |
FLJ45155; GMP140; GRMP; PADGEM; PSEL; P-Selectin; SELP; CD62P; CD62; LECAM3 |
Accession |
|
Species |
Mouse |
Biotinylated |
no |
Amino Acid Range |
Trp42-Ala709 |
Molecular Weight |
The protein has a predicted MW of 81.1 kDa. Due to glycosylation, the protein migrates to 110-130 kDa based on Bis-Tris PAGE result. |
Product Tag |
C-His |
Express System |
HEK293 |
Purity |
> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC |
Endotoxin |
Less than 1EU per ug by the LAL method. |
Form |
Lyophilized |
Shipping |
Shipped at ambient temperature. |
Formulation |
Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution |
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
Stability And Storage |
Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
|
|
Mouse P-Selectin on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
|
|
The purity of Mouse P-Selectin is greater than 95% as determined by SEC-HPLC. |
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