Product Description |
Recombinant Mouse PVRIG Protein is expressed from HEK293 with hFc tag and Avi tag at the C-Terminus.It contains Ser35-Asp165. |
Product Background |
Murine PVRIG interacted weakly with poliovirus receptor (PVR) but bound poliovirus receptor-like 2 (PVRL2) strongly, making the latter its principal ligand.PVRIG is an inducible checkpoint receptor and that targeting PVRIG-PVRL2 interactions results in increased CD8+ T-cell function and reduced tumor growth. |
Product Category |
Recombinant Protein / Antibody discovery / Immune checkpoint proteins |
Protein |
PVRIG |
Synonyms |
C7orf15; CD112R; MGC104322; MGC138297; MGC2463; PVRIG; ALS2CR18; ALS2CR9; LPD; PREL-2; PREL2; RalGDS/AF-6; RMO1 |
Accession |
|
Species |
Mouse |
Biotinylated |
no |
Amino Acid Range |
Ser35-Asp165 |
Molecular Weight |
The protein has a predicted MW of 42.70 kDa. Due to glycosylation, the protein migrates to 53-63 kDa based on Bis-Tris PAGE result. |
Activity |
Immobilized Mouse Nectin-2, His Tag at 5ug/ml (100ul/well) on the plate. Dose response curve for Mouse PVRIG, hFc Tag with the EC50 of 0.62ug/ml determined by ELISA (QC Test). See testing image for detail. |
Product Tag |
C-hFc-Avi |
Expression System |
HEK293 |
Purity |
> 95% as determined by Bis-Tris PAGE |
Endotoxin |
Less than 1EU per ug by the LAL method. |
Form |
Lyophilized |
Shipping |
Shipped at ambient temperature. |
Formulation |
Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution |
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
Stability And Storage |
-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
|
|
Immobilized Mouse Nectin-2, His Tag at 5ug/ml (100ul/well) on the plate. Dose response curve for Mouse PVRIG, hFc Tag with the EC50 of 0.62ug/ml determined by ELISA (QC Test). |
|
|
Mouse PVRIG on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
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