Mouse SEMA7A Protein (SEM-MM17A)
Mouse SEMA7A Protein (SEM-MM17A)
Mouse SEMA7A Protein (SEM-MM17A)
Mouse SEMA7A Protein (SEM-MM17A)
  • Express System: HEK293
  • Product Tag: C-His
  • Purity: > 95% as determined by Bis-Tris PAGE
  • Amino Acid Range: Gln45-Ala646
Catalog #SEM-MM17A
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Product Description
 Recombinant Mouse SEMA7A Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Gln45-Ala646.
Product Background
 Semaphorin7A (Sema7A) plays an important role in the immunoregulation of the brain.Sema7A is upregulated in the epileptic brain and plays a potential role in the regulation of seizure activity in PTZ-kindled epileptic rats, which may be related to neuroinflammation. Sema7A promotes the inflammatory cytokines TNF-α and IL-6 as well as the growth of mossy fibers through the ERK pathway, suggesting that Sema7A may promote seizures by increasing neuroinflammation and activating pathological neural circuits. Sema7A plays a critical role in epilepsy and could be a potential therapeutic target for this neurological disorder.
Product Category
 Recombinant Protein
Target
 SEMA7A
Synonyms
 Semaphorin-7A; Semaphorin-K1; Semaphorin-L; Sema L; CD108; CD108MGC126696; CDw108; H-SEMA-K1; H-Sema-L; JMH; MGC126692; Sema7A; SEMAK1; SEMAL
Accession
Species
 Mouse
Biotinylated
 no
Amino Acid Range
 Gln45-Ala646
Molecular Weight
 The protein has a predicted MW of 69.5 kDa. Due to glycosylation, the protein migrates to 70-80 kDa based on Bis-Tris PAGE result.
Product Tag
 C-His
Express System
 HEK293
Purity
 > 95% as determined by Bis-Tris PAGE
Endotoxin
 Less than 1EU per ug by the LAL method.
Form
 Lyophilized
Shipping
 Shipped at ambient temperature.
Formulation
 Lyophilized from 0.22um filtered solution in PBS, 200mM L-arginine (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution
 Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage
 Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Mouse SEMA7A on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
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