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Mouse TNFRSF11A/Rank Protein, Ultra Low Endotoxin (RNK-MM211-UL) Summary
Product Description |
Recombinant Mouse TNFRSF11A/Rank Protein is expressed from HEK293 with hFc (IgG1) tag at the C-Terminus.It contains Val31-Ser214. |
Product Background |
TNFRSF11A, also known as receptor activator of NF-κB (RANK), activates several signaling pathways, such as NF-κB, JNK, ERK, p38α, and Akt/PKB. RANK/TNFRSF11A is a novel and frequent target for de novo methylation in gliomas, which affects apoptotic activity and focus formation thereby contributing to the molecular pathogenesis of gliomas. |
Product Category |
Recombinant Protein / Antibody discovery / Antibody discovery | Others |
Mouse TNFRSF11A/Rank Protein, Ultra Low Endotoxin (RNK-MM211-UL) Specifications/Details
Protein |
TNFRSF11A/Rank |
Synonyms |
ODFR; Receptor activator of NF-KB; NF-KB; NFKB; CD265; TNFRSF11A; Rank; FEO; LOH18CR1; OPTB7; OSTS; PDB2; TRANCER; |
Accession |
|
Species |
Mouse |
Biotinylated |
no |
Amino Acid Range |
Val31-Ser214 |
Molecular Weight |
The protein has a predicted MW of 47.0 kDa. Due to glycosylation, the protein migrates to 57-67 kDa based on Bis-Tris PAGE result. |
Activity |
Immobilized Mouse RANKL, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Mouse TNFRSF11A, hFc Tag with the EC50 of 5.1ng/ml determined by ELISA. |
Product Tag |
C-hFc (IgG1) |
Fluorophore |
Unconjugated |
Expression System |
HEK293 |
Purity |
> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC |
Endotoxin |
Less than 0.01 EU per ug by the LAL method. |
Shipping, Reconstitution, & Storage
Form |
Lyophilized |
Shipping |
Shipped at ambient temperature. |
Formulation |
Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution |
Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking. |
Stability And Storage |
-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
Validation Images
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Immobilized Mouse RANKL, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Mouse TNFRSF11A, hFc Tag with the EC50 of 5.1ng/ml determined by ELISA. |
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Mouse TNFRSF11A on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
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The purity of Mouse TNFRSF11A is greater than 95% as determined by SEC-HPLC. |
Other Available Proteins:
Finding available proteins...
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