Mouse TREM2 Protein (TRM-MM101)

  • Express System: HEK293
  • Product Tag: C-His
  • Purity: > 95% as determined by Tris-Bis PAGE
  • Activity: Immobilized Mouse TREM2, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Anti-TREM2 Antibody, hFc Tag with the EC50 of 2.5ng/ml determined by ELISA. See testing image for detail.
  • Amino Acid Range: Leu19-Ser171

Catalog: TRM-MM101

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Product Description Recombinant Mouse TREM2 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Leu19-Ser171.

Product Background

TREM-2 (Triggering Receptor Expressed on Myeloid cells-2) is a 35 kDa type I transmembrane member of the TREM family and Ig superfamily. Mature human TREM-2- consists of a 156 amino acid (aa) extracellular domain (ECD) with one V-type Ig-like domain, a 21 aa transmembrane (TM) domain, and a 35 aa cytoplasmic tail. TREM-2 forms a receptor signaling complex with TYROBP which mediates signaling and cell activation following ligand binding (PubMed:10799849). Acts as a receptor for amyloid-beta protein 42, a cleavage product of the amyloid-beta precursor protein APP, and mediates its uptake and degradation by microglia.

Product Category

Recombinant Protein

Target

TREM2
Synonyms PLOSL2; TREM2; TREM-2; Trem2a; Trem2b; Trem2c
Accession

Species

Mouse

Amino Acid Range

Leu19-Ser171
Molecular Weight The protein has a predicted MW of 17.9 kDa. Due to glycosylation, the protein migrates to 35-45 kDa based on Tris-Bis PAGE result.

Activity

Immobilized Mouse TREM2, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Anti-TREM2 Antibody, hFc Tag with the EC50 of 2.5ng/ml determined by ELISA. See testing image for detail.

Product Tag

C-His

Express System

HEK293
Purity > 95% as determined by Tris-Bis PAGE
Endotoxin Less than 1EU per ug by the LAL method.
Form Lyophilized
Shipping Shipped at ambient temperature.
Formulation Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Immobilized Mouse TREM2, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Anti-TREM2 Antibody, hFc Tag with the EC50 of 2.5ng/ml determined by ELISA.
Mouse TREM2 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

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