Mouse WISP1 Protein (WIP-MM101)
Catalog: WIP-MM101
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| Product Description | Recombinant Mouse WISP1 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Thr23-Asn367. |
Product Background |
The interplay between glioma stem cells (GSCs) and the tumor microenvironment plays crucial roles in promoting malignant growth of glioblastoma (GBM), the most lethal brain tumor. WISP1 is preferentially expressed and secreted by GSCs. Silencing WISP1 markedly disrupts GSC maintenance, reduces tumor-supportive TAMs (M2), and potently inhibits GBM growth. WISP1 signals through Integrin α6β1-Akt to maintain GSCs by an autocrine mechanism and M2 TAMs through a paracrine manner. |
Product Category |
Recombinant Protein |
Target |
WISP1 |
| Synonyms | ELM-1; WISP-1; CCN4; WISP1c; WISP1i; WISP1tc |
| Accession | |
Species |
Mouse |
Amino Acid Range |
Thr23-Asn367 |
| Molecular Weight | The protein has a predicted MW of 39.4 kDa. Due to glycosylation, the protein migrates to 64-68 kDa based on Tris-Bis PAGE result. |
Product Tag |
C-His |
Express System |
HEK293 |
| Purity | > 95% as determined by Tris-Bis PAGE |
| Endotoxin | Less than 1EU per ug by the LAL method. |
| Form | Lyophilized |
| Shipping | Shipped at ambient temperature. |
| Formulation | Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
| Reconstitution | Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
| Stability And Storage | Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
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Mouse WISP1 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. |
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