Mouse YKL-40/CHI3L1 Protein (YKL-MM140)
Mouse YKL-40/CHI3L1 Protein (YKL-MM140)
Mouse YKL-40/CHI3L1 Protein (YKL-MM140)
Mouse YKL-40/CHI3L1 Protein (YKL-MM140)
  • Express System: HEK293
  • Product Tag: C-His
  • Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
  • Amino Acid Range: Tyr30-Ala389
Catalog #YKL-MM140
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Product Description
 Recombinant Mouse YKL-40/CHI3L1 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Tyr30-Ala389.
Product Background
 YKL-40 (also known as Chitinase 3-like 1) is a glycoprotein produced by inflammatory, cancer and stem cells. Its physiological role is not completely understood but YKL-40 is elevated in the brain and cerebrospinal fluid (CSF) in several neurological and neurodegenerative diseases associated with inflammatory processes. Yet the precise characterization of YKL-40 in dementia cases is missing. YKL-40 is a disease-specific marker of neuroinflammation showing its highest levels in prion diseases. Therefore, YKL-40 quantification might have a potential for application in the evaluation of therapeutic intervention in dementias with a neuroinflammatory component.
Product Category
 Recombinant Protein
Target
 YKL-40/CHI3L1
Synonyms
 BRP39; CGP-39; GP-39; Chil1; ASRT7; FLJ38139; HC-gp39; YKL-40; YKL40; YYL-40; AW208766; CHI3L1; Chitinase 3 like 1
Accession
Species
 Mouse
Biotinylated
 no
Amino Acid Range
 Tyr30-Ala389
Molecular Weight
 The protein has a predicted MW of 41.9 kDa. Due to glycosylation, the protein migrates to 42-50 kDa based on Bis-Tris PAGE result.
Product Tag
 C-His
Express System
 HEK293
Purity
 > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin
 Less than 1EU per ug by the LAL method.
Form
 Lyophilized
Shipping
 Shipped at ambient temperature.
Formulation
 Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution
 Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage
 Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Mouse YKL-40 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
The purity of Mouse YKL-40 is greater than 95% as determined by SEC-HPLC.
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