Murine RNase Inhibitor, GMP Grade (GMP-RNI-ME101)
Catalog: GMP-RNI-ME101
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| Product Description | RNase inhibitors are essential to protect RNA from RNase contamination. It inhibits the enzymatic activity of RNases by noncovalently binding to the active site. Murine RNase inhibitor is a recombinant RNase inhibitor of murine origin expressed and purified in E.coli. It specifically inactivates RNases such as RNaseA, RNaseB, and C by binding covalently with RNase to form a 1:1 complex. Murine RNase Inhibitor is compatible with RNA synthesis, RT-PCR and other RNA-related reactions. Expressed in an E.coli strain with the RNase inhibitor gene from mouse. |
| Product Category | GMP Enzyme |
| Application | In Vitro Transcription RT-PCR cDNA synthesis |
| Concentration | 40 U/UL |
| Unit Definition | One unit is defined as the amount of Murine RNase Inhibitor required to inhibit the activity of 5ng of RNase A by 50%. Activity is measured by the inhibition of hydrolysis of cytidine 2', 3'-cyclic monophosphate by RNase A. |
| Molecular Weight | 50 kD |
| Express System | E.coli |
| Quality Statement | Manufactured to the GMP guidelines Antibiotic-free and animal-free production Suitable for manufacturing of mRNA therapeutics and vaccines |
| QC Standard | Activity: >=40 kU/ml
Purity: >=95% Residual Endonuclease: Negative Residual Exonuclease: Negative Residual RNase: Negative Residual Protease: Negative Endotoxin: <=10 EU/ml Residual Host Cell DNA: <=100 pg/MG Residual Host Protein: <=50 ng/MG Bioburden: <=1 CFU/10 ml |
| Form | Liquid |
| Shipping | Shipped with blue ice |
| Stability And Storage | -20°C for 12 months. Avoid repeated freeze-thaw cycles. |
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