PE-Labeled Human HLA-A*03:01&B2M&KRAS G12V (VVGAVGVGK) Tetramer Protein (MHC-HM456TP)

  • Express System: HEK293
  • Product Tag: C-His-Avi
  • Amino Acid Range: Gly25-Thr305(HLA-A*03:01), Ile21-Met119(B2M) and VVGAVGVGK peptide

Catalog: MHC-HM456TP

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Product Description Recombinant PE-Labeled Human HLA-A*03:01&B2M&KRAS G12V (VVGAVGVGK) Tetramer Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus. PE-Labeled Human HLA-A*03:01&B2M&KRAS G12V (VVGAVGVGK) Tetramer is assembled by biotinylated monomer and PE-Labeled streptavidin; It contains Gly25-Thr305 (HLA-A*03:01), Ile21-Met119 (B2M) and VVGAVGVGK peptide.

Product Background

Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-priority therapeutic target. The virtual screening approach to discover novel KRAS inhibitors and synthetic lethality interactors of KRAS are discussed in detail.

Product Category

Recombinant Protein

Target

HLA-A*03:01&B2M&KRAS G12V (VVGAVGVGK) Tetramer
Accession
MHC Form Tetramer
Allele HLA-A*03:01

Species

Human

Amino Acid Range

Gly25-Thr305(HLA-A*03:01), Ile21-Met119(B2M) and VVGAVGVGK peptide

Product Tag

C-His-Avi

Fluorophore

PE

Express System

HEK293
Endotoxin Less than 1 EU per ug by the LAL method.
Form Liquid
Shipping Shipped with dry ice.
Formulation Supplied as 0.22 um filtered solution in PBS (pH 7.4).
Stability And Storage Valid for 6 months from date of receipt when stored at -80°C; Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

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