PE-Labeled Human HLA-A*03:01&B2M&KRAS G12V (VVGAVGVGK) Tetramer Protein (MHC-HM456TP)
Catalog: MHC-HM456TP
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| Product Description | Recombinant PE-Labeled Human HLA-A*03:01&B2M&KRAS G12V (VVGAVGVGK) Tetramer Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus. PE-Labeled Human HLA-A*03:01&B2M&KRAS G12V (VVGAVGVGK) Tetramer is assembled by biotinylated monomer and PE-Labeled streptavidin; It contains Gly25-Thr305 (HLA-A*03:01), Ile21-Met119 (B2M) and VVGAVGVGK peptide. |
Product Background |
Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-priority therapeutic target. The virtual screening approach to discover novel KRAS inhibitors and synthetic lethality interactors of KRAS are discussed in detail. |
Product Category |
Recombinant Protein |
Target |
HLA-A*03:01&B2M&KRAS G12V (VVGAVGVGK) Tetramer |
| Accession | |
| MHC Form | Tetramer |
| Allele | HLA-A*03:01 |
Species |
Human |
Amino Acid Range |
Gly25-Thr305(HLA-A*03:01), Ile21-Met119(B2M) and VVGAVGVGK peptide |
Product Tag |
C-His-Avi |
Fluorophore |
PE |
Express System |
HEK293 |
| Endotoxin | Less than 1 EU per ug by the LAL method. |
| Form | Liquid |
| Shipping | Shipped with dry ice. |
| Formulation | Supplied as 0.22 um filtered solution in PBS (pH 7.4). |
| Stability And Storage | Valid for 6 months from date of receipt when stored at -80°C; Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
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