Name: PE-Labeled Human HLA-A*11:01&B2M&KRAS G12D (VVVGADGVGK) Tetramer Protein (MHC-HM420TP)
Brand: KactusBio
SKU: MHC-HM420TP-100UG
Price: 1150.0 USD
Availability: InStock

PE-Labeled Human HLA-A*11:01&B2M&KRAS G12D (VVVGADGVGK) Tetramer Protein (MHC-HM420TP)

Immobilized HLA-A*11:01&B2M&KRAS G12D (VVVGADGVGK) TCR at 1ug/ml (100ul/well) on the plate. Dose response curve for PE-Labeled Human HLA-A*11:01&B2M&KRAS G12D (VVVGADGVGK) Tetramer, His Tag with the EC50 of 96.7ng/ml determined by ELISA.

Express System: HEK293
Product Tag: C-His-Avi
Activity: Immobilized HLA-A*11:01&B2M&KRAS G12D (VVVGADGVGK) TCR at 1ug/ml (100ul/well) on the plate. Dose response curve for PE-Labeled Human HLA-A*11:01&B2M&KRAS G12D (VVVGADGVGK) Tetramer, His Tag with the EC50 of 96.7ng/ml determined by ELISA. See testing image for detail.
Amino Acid Range: Gly25-Thr305(HLA-A*11:01), Ile21-Met119(B2M) and VVVGADGVGK peptide

Catalog #MHC-HM420TP

Size

100UG

500UG

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Product Description	Recombinant PE-Labeled Human HLA-A11:01&B2M&KRAS G12D (VVVGADGVGK) Tetramer Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus. PE-labeled Human HLA-A11:01&B2M&KRAS G12D (VVVGADGVGK) Tetramer is assembled by biotinylated monomer and PE-Labeled streptavidin.It contains Gly25-Thr305(HLA-A*11:01), Ile21-Met119(B2M) and VVVGADGVGK peptide.
Product Background	Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-priority therapeutic target. The virtual screening approach to discover novel KRAS inhibitors and synthetic lethality interactors of KRAS are discussed in detail.
Product Category	Recombinant Protein / Antibody discovery / MHC

Protein	HLA-A*11:01&B2M&KRAS G12D (VVVGADGVGK) Tetramer
Synonyms	MHC; KRAS; K-Ras 2; KRAS2; C-K-RAS; CFC2; K-RAS2A; K-RAS2B; K-RAS4A; K-RAS4B; KRAS1; KRAS2; NS; NS3; RASK2; GTPase Kras; KI-RAS; RALD
MHC Form	Tetramer
Allele	HLA-A*11:01
Accession	AAV53343.1(HLA-A*11:01)&P61769(B2M)&VVVGADGVGK
Species	Human
Biotinylated	no
Amino Acid Range	Gly25-Thr305(HLA-A*11:01), Ile21-Met119(B2M) and VVVGADGVGK peptide
Activity	Immobilized HLA-A11:01&B2M&KRAS G12D (VVVGADGVGK) TCR at 1ug/ml (100ul/well) on the plate. Dose response curve for PE-Labeled Human HLA-A11:01&B2M&KRAS G12D (VVVGADGVGK) Tetramer, His Tag with the EC50 of 96.7ng/ml determined by ELISA. See testing image for detail.
Product Tag	C-His-Avi
Fluorophore	PE
Expression System	HEK293
Endotoxin	Less than 1EU per ug by the LAL method.

Form	Liquid
Shipping	Shipped with dry ice.
Formulation	Supplied as 0.22um filtered solution in PBS, 0.2% BSA (pH 7.4).
Stability And Storage	Valid for 6 months from date of receipt when stored at -80°C.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Immobilized HLA-A*11:01&B2M&KRAS G12D (VVVGADGVGK) TCR at 1ug/ml (100ul/well) on the plate. Dose response curve for PE-Labeled Human HLA-A*11:01&B2M&KRAS G12D (VVVGADGVGK) Tetramer, His Tag with the EC50 of 96.7ng/ml determined by ELISA.

Additional Information

Learn More: MHC Collection Learn More: Peptide-ready MHC Protocol: MHC Staining Case Study: Peptide-ready MHC for TCR Staining Poster: Engineering MHCs as Versatile Reagents Publication: Use of our Peptide-Ready MHCs in CAR-T Cell Research Product Brochure