Regular price
$1,050.00
Order by 4pm ET for delivery on:
PE-Labeled Human HLA-A*02:01&B2M&P53 WT (HMTEVVRRC) Tetramer Protein (MHC-HM416TP) Summary
Product Description |
Recombinant PE-Labeled Human HLA-A*02:01&B2M&P53 WT (HMTEVVRRC) Tetramer Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus. PE-Labeled Human HLA-A*02:01&B2M&P53 WT (HMTEVVRRC) Tetramer is assembled by biotinylated monomer and PE-labeled streptavidin. It contains Gly25-Thr305(HLA-A*02:01), Ile21-Met119(B2M) and HMTEVVRRC peptide. |
Product Background |
p53 is a tumor suppressor protein. Under stressful conditions, p53 tightly regulates cell growth by promoting apoptosis and DNA repair. When p53 becomes mutated, it loses its function, resulting in abnormal cell proliferation and tumor progression. Depending on the p53 mutation, it has been shown to form aggregates leading to negative gain of function of the protein. p53 mutant associated aggregation has been observed in several cancer tissues and has been shown to promote tumor growth. |
Product Category |
Recombinant Protein / Antibody discovery / MHC / Peptide-MHCs |
HLA-A*02:01&B2M&P53 WT (HMTEVVRRC) Specifications
Protein |
HLA-A*02:01&B2M&P53 WT (HMTEVVRRC) |
Synonyms |
MHC; HLA-A; P53; TP53; Antigen NY-CO-13; BCC7; FLJ92943; LFS1; TRP53 |
MHC Form |
Tetramer |
Allele |
HLA-A*02:01 |
Accession |
A0A140T913(HLA-A*02:01)&P61769(B2M)&HMTEVVRRC |
Species |
Human |
Biotinylated |
no |
Amino Acid Range |
Gly25-Thr305(HLA-A*02:01), Ile21-Met119(B2M) and HMTEVVRRC peptide |
Activity |
Immobilized PE-Labeled Human HLA-A*02:01&B2M&P53 WT (HMTEVVRRC) Tetramer, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Anti-B2M Antibody, mFc Tag with the EC50 of 1.6ng/ml determined by ELISA. |
Product Tag |
C-His-Avi |
Fluorophore |
PE-Labeled |
Expression System |
HEK293 |
Shipping, Reconstitution, & Storage
Form |
Liquid |
Shipping |
Shipped with dry ice. |
Formulation |
Supplied as 0.22um filtered solution in PBS, 0.2% BSA (pH 7.4). |
Stability And Storage |
Valid for 6 months from date of receipt when stored at -80°C.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles and protect from light. |
Validation Images
|
|
Immobilized PE-Labeled Human HLA-A*02:01&B2M&P53 WT (HMTEVVRRC) Tetramer, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Anti-B2M Antibody, mFc Tag with the EC50 of 1.6ng/ml determined by ELISA. |
Additional Information
Other Available Proteins:
Finding available proteins...
Related Products
Have more questions?
Check out our Frequently Asked Questions page for more details about product specifications, ordering, and shipments.
Contact Us
Recommended Products
Loading...
Recently viewed
