Rabbit Coagulation factor XI Protein (FXI-RM101)
  • Express System: HEK293
  • Product Tag: C-His
  • Purity: >95% as determined by Bis-Tris PAGE;>95% as determined by HPLC
  • Activity: Immobilized Rabbit Coagulation factor XI, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Anti-factor XI Antibody, hFc Tag with the EC50 of 4.5ng/ml determined by ELISA (QC Test). See testing image for detail.
  • Amino Acid Range: Glu19-Pro624
Catalog #FXI-RM101
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Product Description
 Recombinant Rabbit Coagulation factor XI Protein is expressed from HEK293 with His tag at the C-terminus.It contains Glu19-Pro624.
Product Background
 Coagulation factor (F)XI has been described as a component of the early phase of the contact pathway of blood coagulation, acting downstream of factor XII.In contrast to its mild hemostatic activities, FXI is known to play a significant role in thrombosis, as it is a demonstrated independent risk factor for deep vein thrombosis, ischemic stroke, and myocardial infarction. A better understanding of the varied and complex role of FXI in both thrombosis and hemostasis will help to allow better prediction of bleeding risk in FXI-deficient patients and also informing the development of targeted agents to inhibit the thrombotic activities of FXI while preserving hemostasis.
Product Category
 Recombinant Protein
Target
 Coagulation factor XI
Synonyms
 Coagulation factor XI; FXI; PTA; F11;
Accession
Species
 Rabbit
Biotinylated
 no
Amino Acid Range
 Glu19-Pro624
Molecular Weight
 The protein has a predicted MW of 69.61 kDa. Due to glycosylation, the protein migrates to 70-90 kDa based on Bis-Tris PAGE result.
Activity
 Immobilized Rabbit Coagulation factor XI, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Anti-factor XI Antibody, hFc Tag with the EC50 of 4.5ng/ml determined by ELISA (QC Test). See testing image for detail.
Product Tag
 C-His
Express System
 HEK293
Purity
 >95% as determined by Bis-Tris PAGE;>95% as determined by HPLC
Endotoxin
 Less than 1EU per ug by the LAL method.
Form
 Liquid
Shipping
 Shipped with dry ice.
Formulation
 Supplied as 0.22 um filtered solution in PBS (pH 7.4).
Stability And Storage
 Valid for 12 months from date of receipt when stored at -80°C.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Immobilized Rabbit Coagulation factor XI, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Anti-factor XI Antibody, hFc Tag with the EC50 of 4.5ng/ml determined by ELISA (QC Test).
Rabbit Coagulation factor XI on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
The purity of Rabbit Coagulation factor XI is greater than 95% as determined by SEC-HPLC.

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