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Rabbit Coagulation factor XI Protein (FXI-RM101) Summary
Product Description |
Recombinant Rabbit Coagulation factor XI Protein is expressed from HEK293 with His tag at the C-terminus.It contains Glu19-Pro624. |
Product Background |
Coagulation factor (F)XI has been described as a component of the early phase of the contact pathway of blood coagulation, acting downstream of factor XII.In contrast to its mild hemostatic activities, FXI is known to play a significant role in thrombosis, as it is a demonstrated independent risk factor for deep vein thrombosis, ischemic stroke, and myocardial infarction. A better understanding of the varied and complex role of FXI in both thrombosis and hemostasis will help to allow better prediction of bleeding risk in FXI-deficient patients and also informing the development of targeted agents to inhibit the thrombotic activities of FXI while preserving hemostasis. |
Product Category |
Recombinant Protein / Antibody discovery / Antibody discovery | Others |
Rabbit Coagulation factor XI Protein (FXI-RM101) Specifications/Details
Protein |
Coagulation factor XI |
Synonyms |
Coagulation factor XI; FXI; PTA; F11; |
Accession |
|
Species |
Rabbit |
Biotinylated |
no |
Amino Acid Range |
Glu19-Pro624 |
Molecular Weight |
The protein has a predicted MW of 69.61 kDa. Due to glycosylation, the protein migrates to 70-90 kDa based on Bis-Tris PAGE result. |
Activity |
Immobilized Rabbit Coagulation factor XI, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Anti-factor XI Antibody, hFc Tag with the EC50 of 4.5ng/ml determined by ELISA (QC Test). |
Product Tag |
C-His |
Fluorophore |
Unconjugated |
Expression System |
HEK293 |
Purity |
> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC |
Endotoxin |
Less than 1 EU per ug by the LAL method. |
Shipping, Reconstitution, & Storage
Form |
Liquid |
Shipping |
Shipped with dry ice. |
Formulation |
Supplied as 0.22 um filtered solution in PBS (pH 7.4). |
Stability And Storage |
Valid for 12 months from date of receipt when stored at -80°C.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
Validation Images
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Immobilized Rabbit Coagulation factor XI, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Anti-factor XI Antibody, hFc Tag with the EC50 of 4.5ng/ml determined by ELISA (QC Test). |
|
|
Rabbit Coagulation factor XI on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
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The purity of Rabbit Coagulation factor XI is greater than 95% as determined by SEC-HPLC. |
Other Available Proteins:
Finding available proteins...
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