Rat GFRAL/GFR alpha-like Protein (GFL-RM101)

  • Express System: HEK293
  • Product Tag: N-His
  • Purity: > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
  • Activity: Immobilized Rat GFRAL, His Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Human GDF15, hFc Tag with the EC50 of 4.4ng/ml determined by ELISA. See testing image for detail.
  • Exact Sequence: Gln20-Gly350

Catalog: GFL-RM101

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Product Description Recombinant Rat GFRAL/GFR alpha-like Protein is expressed from HEK293 with His tag at the N-terminus.It contains Gln20-Gly350.

Product Background

GFR alpha -like (GDNF receptor-alpha-like) is a distant member of the GDNFR family of proteins. Mature human GFR alpha-like is a 376 amino acid (aa) type I transmembrane protein. It contains a 333 aa extracellular domain, a 20 aa transmembrane domain and a 23 aa cytoplasmic domain.GFRAL is a brainstem-restricted receptor for GDF15 which regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses.

Product Category

Recombinant Protein

Target

GFRAL/GFR alpha-like

Gene/Protein ID

D3ZB94

Species

Rat

Exact Sequence

Gln20-Gly350
Molecular Weight The protein has a predicted MW of 38.17 kDa. Due to glycosylation, the protein migrates to 45-55 kDa based on Tris-Bis PAGE result.

Activity

Immobilized Rat GFRAL, His Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Human GDF15, hFc Tag with the EC50 of 4.4ng/ml determined by ELISA. See testing image for detail.

Product Tag

N-His

Express System

HEK293
Purity > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
Endotoxin Less than 1EU per ug by the LAL method.
Form Liquid
Shipping Shipped with dry ice.
Formulation Supplied as 0.22 um filtered solution in PBS (pH 7.4).
Stability And Storage Valid for 12 months from date of receipt when stored at -80°C.; Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Immobilized Rat GFRAL, His Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Human GDF15, hFc Tag with the EC50 of 4.4ng/ml determined by ELISA.
The purity of Rat GFRAL is greater than 95% as determined by SEC-HPLC.
Rat GFRAL on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

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