Product Description |
Recombinant Rat IL-22R alpha 1 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains His16-Ala228. |
Product Background |
Interleukin (IL)-22 is a member of the IL-10 family of cytokines and represents an important effector molecule of activated Th22, Th1, and Th17 cells, as well as Tc-cell subsets, gammadelta T cells, natural killer (NK), and NKT cells. IL-22 mediates its effects via a heterodimeric transmembrane receptor complex consisting of IL-22R1 and IL-10R2 and subsequent Janus kinase-signal transducers and activators of transcription (JAK-STAT) signaling pathways including Jak1, Tyk2, and STAT3. |
Product Category |
Recombinant Protein / Antibody discovery / Antibody discovery | Others |
Protein |
IL-22R alpha 1 |
Synonyms |
IL-22R-alpha-1; IL-22RA1; CRF2-9; IL22R; IL22R1; IL-TIF-R1; zcytoR11 |
Accession |
|
Species |
Rat |
Biotinylated |
no |
Amino Acid Range |
His16-Ala228 |
Molecular Weight |
The protein has a predicted MW of 25.42 kDa. Due to glycosylation, the protein migrates to 37-45 kDa based on Bis-Tris PAGE result. |
Activity |
The affinity constant of 0.145 uM as determined in SPR assay (Biacore T200). See testing image for detail. |
Product Tag |
C-His |
Expression System |
HEK293 |
Purity |
> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC |
Endotoxin |
Less than 1 EU per ug by the LAL method. |
Form |
Lyophilized |
Shipping |
Shipped at ambient temperature. |
Formulation |
Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution |
Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking. |
Stability And Storage |
-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
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Rat IL-22R alpha 1, His Tag immobilized on CM5 Chip can bind Biotinylated Mouse IL-22, His Tag with an affinity constant of 0.145 uM as determined in SPR assay (Biacore T200). |
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Rat IL-22R alpha 1 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
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The purity of Rat IL-22R alpha 1 is greater than 95% as determined by SEC-HPLC. |
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