Rat IL-22R alpha 1 Protein (ILR-RM122)
Rat IL-22R alpha 1 Protein (ILR-RM122)
  • Express System: HEK293
  • Product Tag: C-His
  • Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
  • Activity: The affinity constant of 0.145 uM as determined in SPR assay (Biacore T200). See testing image for detail.
  • Amino Acid Range: His16-Ala228
Catalog #ILR-RM122
Regular price $300.00
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Product Description

Recombinant Rat IL-22R alpha 1 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains His16-Ala228.

Product Background

Interleukin (IL)-22 is a member of the IL-10 family of cytokines and represents an important effector molecule of activated Th22, Th1, and Th17 cells, as well as Tc-cell subsets, gammadelta T cells, natural killer (NK), and NKT cells. IL-22 mediates its effects via a heterodimeric transmembrane receptor complex consisting of IL-22R1 and IL-10R2 and subsequent Janus kinase-signal transducers and activators of transcription (JAK-STAT) signaling pathways including Jak1, Tyk2, and STAT3.

Product Category

Recombinant Protein / Antibody discovery

Protein

IL-22R alpha 1

Synonyms

IL-22R-alpha-1; IL-22RA1; CRF2-9; IL22R; IL22R1; IL-TIF-R1; zcytoR11

Accession

Species

Rat

Biotinylated

no

Amino Acid Range

His16-Ala228

Molecular Weight

The protein has a predicted MW of 25.42 kDa. Due to glycosylation, the protein migrates to 37-45 kDa based on Bis-Tris PAGE result.

Activity

The affinity constant of 0.145 uM as determined in SPR assay (Biacore T200). See testing image for detail.

Product Tag

C-His

Expression System

HEK293

Purity

> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC

Endotoxin

Less than 1EU per ug by the LAL method.
Form
Lyophilized
Shipping
Shipped at ambient temperature.
Formulation
Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage
-20 to -80°C for 12 months as supplied from date of receipt.;-80°C for 3 months after reconstitution.;Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Rat IL-22R alpha 1, His Tag immobilized on CM5 Chip can bind Biotinylated Mouse IL-22, His Tag with an affinity constant of 0.145 uM as determined in SPR assay (Biacore T200). Rat IL-22R alpha 1, His Tag immobilized on CM5 Chip can bind Biotinylated Mouse IL-22, His Tag with an affinity constant of 0.145 uM as determined in SPR assay (Biacore T200).
Rat IL-22R alpha 1 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. Rat IL-22R alpha 1 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
The purity of Rat IL-22R alpha 1 is greater than 95% as determined by SEC-HPLC. The purity of Rat IL-22R alpha 1 is greater than 95% as determined by SEC-HPLC.

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