
- Express System: HEK293
- Product Tag: C-hFc
- Purity: >95% as determined by Bis-Tris PAGE
- Activity: The affinity constant of 3.79 nM as determined in SPR assay (Biacore T200). See testing image for detail.
- Amino Acid Range: Gly39-Asp367
Product Description |
Recombinant Rat IL-23R Protein is expressed from HEK293 with hFc tag at the C-terminus.It contains Gly39-Asp367. |
Product Background |
Interleukin-23 (IL-23), a member of the IL-12 family of cytokines, is a heterodimeric cytokine. It is composed of subunits p40 (shared with IL-12) and p19 (an IL-12 p35-related subunit) and is secreted by several types of immune cells, such as natural killer cells and dendritic cells. The IL-23 receptor is composed of the subunit IL-12Rβ1 and the IL-23-specific subunit IL-23R. The binding of IL-23 to its specific cell surface receptor regulates a number of functions, including proliferation and differentiation of cells and secretion of cell factors. |
Product Category |
Recombinant Protein / Antibody discovery |
Protein |
IL-23R |
Synonyms |
IBD17; IL-23 R; IL-23 receptor |
Accession |
|
Species |
Rat |
Biotinylated |
no |
Amino Acid Range |
Gly39-Asp367 |
Molecular Weight |
The protein has a predicted MW of 63.61 kDa. Due to glycosylation, the protein migrates to 90-120 kDa based on Bis-Tris PAGE result. |
Activity |
The affinity constant of 3.79 nM as determined in SPR assay (Biacore T200). See testing image for detail. |
Product Tag |
C-hFc |
Expression System |
HEK293 |
Purity |
>95% as determined by Bis-Tris PAGE |
Endotoxin |
Less than 1EU per ug by the LAL method. |
Form |
Lyophilized |
Shipping |
Shipped at ambient temperature. |
Formulation |
Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution |
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
Stability And Storage |
-20 to -80°C for 12 months as supplied from date of receipt.;-80°C for 3 months after reconstitution.;Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
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