Rat IL-23R Protein (ILR-RM223)
  • Express System: HEK293
  • Product Tag: C-hFc
  • Purity: >95% as determined by Bis-Tris PAGE;>95% as determined by HPLC
  • Activity: The affinity constant of 3.79 nM as determined in SPR assay (Biacore T200). See testing image for detail.
  • Amino Acid Range: Gly39-Asp367
Catalog #ILR-RM223
Regular price $346.50
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Product Description

Recombinant Rat IL-23R Protein is expressed from HEK293 with hFc tag at the C-terminus.It contains Gly39-Asp367.

Product Background

Interleukin 23 (IL-23) is a heterodimeric cytokine composed of two disulfide-linked subunits, a p19 subunit that is unique to IL-23, and a p40 subunit that is shared with IL-12. The functional IL-23 receptor complex consists of two receptor subunits, the IL-12 receptor beta 1 subunit (IL-12 R beta 1) and the IL-23-specific receptor subunit (IL-23 R).This receptor associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade.

Product Category

Recombinant Protein / Antibody discovery

Protein

IL-23R

Synonyms

IBD17; IL-23 R; IL-23 receptor

Accession

Species

Rat

Biotinylated

no

Amino Acid Range

Gly39-Asp367

Molecular Weight

The protein has a predicted MW of 63.61 kDa. Due to glycosylation, the protein migrates to 90-120 kDa based on Bis-Tris PAGE result.

Activity

The affinity constant of 3.79 nM as determined in SPR assay (Biacore T200). See testing image for detail.

Product Tag

C-hFc

Expression System

HEK293

Purity

>95% as determined by Bis-Tris PAGE;>95% as determined by HPLC

Endotoxin

Less than 1EU per ug by the LAL method.
Form
Lyophilized
Shipping
Shipped at ambient temperature.
Formulation
Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage
-20 to -80°C for 12 months as supplied from date of receipt.;-80°C for 3 months after reconstitution.;Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Rat IL-23R, hFc Tag captured on CM5 Chip via Protein A can bind Human IL-23 alpha&IL-12 beta, His Tag with an affinity constant of 3.79 nM as determined in SPR assay (Biacore T200). Rat IL-23R, hFc Tag captured on CM5 Chip via Protein A can bind Human IL-23 alpha&IL-12 beta, His Tag with an affinity constant of 3.79 nM as determined in SPR assay (Biacore T200).
Rat IL-23R on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. Rat IL-23R on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
The purity of Rat IL-23R is greater than 95% as determined by SEC-HPLC. The purity of Rat IL-23R is greater than 95% as determined by SEC-HPLC.

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