Rat IL-23R Protein (ILR-RM223)
  • Express System: HEK293
  • Product Tag: C-hFc
  • Purity: >95% as determined by Bis-Tris PAGE
  • Activity: The affinity constant of 3.79 nM as determined in SPR assay (Biacore T200). See testing image for detail.
  • Amino Acid Range: Gly39-Asp367
Catalog #ILR-RM223
Regular price $346.50
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Product Description

Recombinant Rat IL-23R Protein is expressed from HEK293 with hFc tag at the C-terminus.It contains Gly39-Asp367.

Product Background

Interleukin-23 (IL-23), a member of the IL-12 family of cytokines, is a heterodimeric cytokine. It is composed of subunits p40 (shared with IL-12) and p19 (an IL-12 p35-related subunit) and is secreted by several types of immune cells, such as natural killer cells and dendritic cells. The IL-23 receptor is composed of the subunit IL-12Rβ1 and the IL-23-specific subunit IL-23R. The binding of IL-23 to its specific cell surface receptor regulates a number of functions, including proliferation and differentiation of cells and secretion of cell factors.

Product Category

Recombinant Protein / Antibody discovery

Protein

IL-23R

Synonyms

IBD17; IL-23 R; IL-23 receptor

Accession

Species

Rat

Biotinylated

no

Amino Acid Range

Gly39-Asp367

Molecular Weight

The protein has a predicted MW of 63.61 kDa. Due to glycosylation, the protein migrates to 90-120 kDa based on Bis-Tris PAGE result.

Activity

The affinity constant of 3.79 nM as determined in SPR assay (Biacore T200). See testing image for detail.

Product Tag

C-hFc

Expression System

HEK293

Purity

>95% as determined by Bis-Tris PAGE

Endotoxin

Less than 1EU per ug by the LAL method.
Form
Lyophilized
Shipping
Shipped at ambient temperature.
Formulation
Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage
-20 to -80°C for 12 months as supplied from date of receipt.;-80°C for 3 months after reconstitution.;Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Rat IL-23R, hFc Tag captured on CM5 Chip via Protein A can bind Human IL-23 alpha&IL-12 beta, His Tag with an affinity constant of 3.79 nM as determined in SPR assay (Biacore T200). Rat IL-23R, hFc Tag captured on CM5 Chip via Protein A can bind Human IL-23 alpha&IL-12 beta, His Tag with an affinity constant of 3.79 nM as determined in SPR assay (Biacore T200).
Rat IL-23R on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. Rat IL-23R on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

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