Sensorgram showing SPR binding response of multiple analyte concentrations over time, illustrating association and dissociation phases for kinetic analysis.
  • Express System: HEK293
  • Product Tag: C-hFc
  • Purity: > 95% as determined by Bis-Tris PAGE
  • Activity: The affinity constant of 3.79 nM as determined in SPR assay (Biacore T200). See testing image for detail.
  • Amino Acid Range: Gly39-Asp367
Catalog #ILR-RM223
Regular price $346.50
/
Size

Order now, ships by:

Rat IL-23R Protein (ILR-RM223) Summary

Product Description

Recombinant Rat IL-23R Protein is expressed from HEK293 with hFc tag at the C-terminus.It contains Gly39-Asp367.

Product Background

Interleukin-23 (IL-23), a member of the IL-12 family of cytokines, is a heterodimeric cytokine. It is composed of subunits p40 (shared with IL-12) and p19 (an IL-12 p35-related subunit) and is secreted by several types of immune cells, such as natural killer cells and dendritic cells. The IL-23 receptor is composed of the subunit IL-12Rβ1 and the IL-23-specific subunit IL-23R. The binding of IL-23 to its specific cell surface receptor regulates a number of functions, including proliferation and differentiation of cells and secretion of cell factors.

Product Category

Recombinant Protein / Antibody discovery / Antibody discovery | Others

Rat IL-23R Protein (ILR-RM223) Specifications/Details

Protein
IL-23R
Synonyms
IBD17; IL-23 R; IL-23 receptor
Accession
Species
Rat
Biotinylated
no
Amino Acid Range
Gly39-Asp367
Molecular Weight
The protein has a predicted MW of 63.61 kDa. Due to glycosylation, the protein migrates to 90-120 kDa based on Bis-Tris PAGE result.
Activity
The affinity constant of 3.79 nM as determined in SPR assay (Biacore T200). See testing image for detail.

Product Tag

C-hFc
Expression System
HEK293
Purity
> 95% as determined by Bis-Tris PAGE
Endotoxin
Less than 1 EU per ug by the LAL method.
Form
Lyophilized
Shipping
Shipped at ambient temperature.
Formulation
Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution
Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking.
Stability And Storage
-20 to -80°C for 12 months as supplied from date of receipt.;-80°C for 3 months after reconstitution.;Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Rat IL-23R, hFc Tag captured on CM5 Chip via Protein A can bind Human IL-23 alpha&IL-12 beta, His Tag with an affinity constant of 3.79 nM as determined in SPR assay (Biacore T200). Rat IL-23R, hFc Tag captured on CM5 Chip via Protein A can bind Human IL-23 alpha&IL-12 beta, His Tag with an affinity constant of 3.79 nM as determined in SPR assay (Biacore T200).
Rat IL-23R on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. Rat IL-23R on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
Have more questions?

Check out our Frequently Asked Questions page for more details about product specifications, ordering, and shipments.

Recently viewed