Rhesus macaque Complement Factor D/CFD Protein (CFD-CM101)

  • Express System: HEK293
  • Product Tag: C-His
  • Purity: > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
  • Activity: Immobilized Rhesus macaque Complement Factor D, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Anti-Complement Factor D Antibody, hFc Tag with the EC50 of 16.3ng/ml determined by ELISA. See testing image for detail.
  • Amino Acid Range: Gln21-Ala253

Catalog: CFD-CM101

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Product Description Recombinant Rhesus macaque Complement Factor D/CFD Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Gln21-Ala253.

Product Background

Complement factor D is a serine protease essential for the activation of the alternative pathway and is expressed in the kidney, adipocytes, and macrophages. Factor D is found at relatively high levels in glomeruli suggesting that this component of the complement cascade could influence renal pathophysiology.Complement factor D or alternative pathway activation is needed to prevent spontaneous accumulation of C3 and IgM deposits within the mesangium.

Product Category

Recombinant Protein

Target

Complement Factor D/CFD
Synonyms Adipsin; C3 convertase activator; Complement factor D; CFD; PFD; DF; ADN; FACTOR D; AMBP-1; EC 3.4.21; EC 3.4.21.46
Accession

Species

Rhesus macaque

Amino Acid Range

Gln21-Ala253
Molecular Weight The protein has a predicted MW of 25.7 kDa. Due to glycosylation, the protein migrates to 26-30 kDa based on Tris-Bis PAGE result.

Activity

Immobilized Rhesus macaque Complement Factor D, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Anti-Complement Factor D Antibody, hFc Tag with the EC50 of 16.3ng/ml determined by ELISA. See testing image for detail.

Product Tag

C-His

Express System

HEK293
Purity > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
Endotoxin Less than 1EU per ug by the LAL method.
Form Lyophilized
Shipping Shipped at ambient temperature.
Formulation Lyophilized from 0.22um filtered solution in 50mM Tris, 150mM NaCl (pH 8.0). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Immobilized Rhesus macaque Complement Factor D, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Anti-Complement Factor D Antibody, hFc Tag with the EC50 of 16.3ng/ml determined by ELISA.
The purity of Rhesus macaque Complement Factor D is greater than 95% as determined by SEC-HPLC.
Rhesus macaque Complement Factor D on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

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