Rhesus macaque Integrin alpha V beta 8 (ITGAV&ITGB8) Heterodimer Protein (ITG-RM1V8)
Rhesus macaque Integrin alpha V beta 8 (ITGAV&ITGB8) Heterodimer Protein (ITG-RM1V8)
  • Express System: HEK293
  • Product Tag: C-His
  • Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
  • Activity: Immobilized Rhesus macaque ITGAV&ITGB8, His Tag at 5ug/ml (100ul/well) on the plate. Dose response curve for Anti-alpha-v Antibody , hFc Tag with the EC50 of 11.6ng/ml determined by ELISA. See testing image for detail.
  • Amino Acid Range: Phe31-Pro993(ITGAV) acidic tail & Glu43-Ser681(ITGB8) basic tail
Catalog #ITG-RM1V8
Regular price $412.50
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Rhesus macaque Integrin alpha V beta 8 (ITGAV&ITGB8) Heterodimer Protein (ITG-RM1V8) Summary

Product Description

Recombinant Rhesus macaque Integrin alpha V beta 8 (ITGAV&ITGB8) Heterodimer Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Phe31-Pro993 (ITGAV) acidic tail and Glu43-Ser681 (ITGB8) basic tail.

Product Background

Deletions of the genes encoding the integrin αVβ8 (Itgav, Itgb8) have been shown to result in abnormal vascular development in the CNS, including prenatal and perinatal hemorrhage. Other work has indicated that a major function of this integrin in vivo is to promote TGFβ activation.

Product Category

Recombinant Protein / Antibody discovery / Antibody discovery | Others

Rhesus macaque Integrin alpha V beta 8 (ITGAV&ITGB8) Heterodimer Protein (ITG-RM1V8) Specifications/Details

Protein
Integrin alpha V beta 8 (ITGAV&ITGB8) Heterodimer
Synonyms
αVβ8; Integrin alpha V beta 8;ITGAV&ITGB8;Integrin alpha V β 8
Accession
Species
Rhesus macaque
Biotinylated
no
Amino Acid Range
Phe31-Pro993(ITGAV) acidic tail & Glu43-Ser681(ITGB8) basic tail
Molecular Weight
The protein has a predicted MW of 112.1 kDa (ITGAV) and 75.3 kDa (ITGB8). Due to glycosylation, the protein migrates to 90-140 kDa based on Bis-Tris PAGE result.
Activity
Immobilized Rhesus macaque ITGAV&ITGB8, His Tag at 5ug/ml (100ul/well) on the plate. Dose response curve for Anti-alpha-v Antibody , hFc Tag with the EC50 of 11.6ng/ml determined by ELISA. See testing image for detail.
Product Tag
C-His
Expression System
HEK293
Purity
> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin
Less than 1 EU per ug by the LAL method.

Shipping, Reconstitution, & Storage

Form
Lyophilized
Shipping
Shipped at ambient temperature.
Formulation
Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution
Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking.
Stability And Storage
-20 to -80°C for 24 months as supplied from date of receipt.;-80°C for 3 months after reconstitution.;Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Validation Images

Immobilized Rhesus macaque ITGAV&ITGB8, His Tag at 5ug/ml (100ul/well) on the plate. Dose response curve for Anti-alpha-v Antibody , hFc Tag with the EC50 of 11.6ng/ml determined by ELISA. Immobilized Rhesus macaque ITGAV&ITGB8, His Tag at 5ug/ml (100ul/well) on the plate. Dose response curve for Anti-alpha-v Antibody , hFc Tag with the EC50 of 11.6ng/ml determined by ELISA.
Rhesus macaque ITGAV&ITGB8 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. Rhesus macaque ITGAV&ITGB8 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
The purity of Rhesus macaque ITGAV&ITGB8 is greater than 95% as determined by SEC-HPLC. The purity of Rhesus macaque ITGAV&ITGB8 is greater than 95% as determined by SEC-HPLC.
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