SARS PLpro/papain-like protease Protein (SAR-VE1PL)
Catalog: SAR-VE1PL
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| Product Description | Recombinant SARS-CoV-2 PLpro/papain-like protease Protein is expressed from E.coil with His tag and Avi tag at the N-Terminus.It contains Glu1-Ile314. |
Product Background |
The coronaviral proteases, papain-like protease (PLpro) and 3C-like protease (3CLpro), are attractive antiviral drug targets because they are essential for coronaviral replication. Although the primary function of PLpro and 3CLpro are to process the viral polyprotein in a coordinated manner, PLpro has the additional function of stripping ubiquitin and ISG15 from host-cell proteins to aid coronaviruses in their evasion of the host innate immune responses. |
Product Category |
Recombinant Protein |
Target |
PLpro/papain-like protease |
| Synonyms | Replicase polyprotein 1a; pp1a; nsp1; PL2-PRO; PL-PRO; Papain-like Protease; Plpro |
Gene/Protein ID |
P0C6U8 |
Species |
SARS |
Exact Sequence |
Glu1-Ile314 |
| Molecular Weight | The protein has a predicted MW of 38.6 kDa same as Tris-Bis PAGE result. |
Product Tag |
N-His-Avi |
Express System |
E.coli |
| Purity | > 95% as determined by Tris-Bis PAGE |
| Endotoxin | Less than 1EU per ug by the LAL method. |
| Form | Liquid |
| Shipping | Shipped with dry ice. |
| Formulation | Supplied as 0.22um filtered solution in 20mM Tris, 100mM NaCl, 10% Glycerol (pH 7.8). |
| Stability And Storage | Valid for 12 months from date of receipt when stored at -80°C.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
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SARS-CoV-2 PLpro on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. |
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