Product Description |
Recombinant SARS-CoV-2 PLpro/papain-like protease Protein is expressed from E.coil with His tag and Avi tag at the N-Terminus.It contains Glu1-Ile314. |
Product Background |
The coronaviral proteases, papain-like protease (PLpro) and 3C-like protease (3CLpro), are attractive antiviral drug targets because they are essential for coronaviral replication. Although the primary function of PLpro and 3CLpro are to process the viral polyprotein in a coordinated manner, PLpro has the additional function of stripping ubiquitin and ISG15 from host-cell proteins to aid coronaviruses in their evasion of the host innate immune responses. |
Product Category |
Recombinant Protein |
Target |
PLpro/papain-like protease |
Synonyms |
Replicase polyprotein 1a; pp1a; nsp1; PL2-PRO; PL-PRO; Papain-like Protease; Plpro |
Accession |
|
Species |
SARS |
Biotinylated |
no |
Amino Acid Range |
Glu1-Ile314 |
Molecular Weight |
The protein has a predicted MW of 38.6 kDa same as Bis-Tris PAGE result. |
Product Tag |
N-His-Avi |
Express System |
E.coli |
Purity |
> 95% as determined by Bis-Tris PAGE |
Endotoxin |
Less than 1EU per ug by the LAL method. |
Form |
Liquid |
Shipping |
Shipped with dry ice. |
Formulation |
Supplied as 0.22um filtered solution in 20mM Tris, 100mM NaCl, 10% Glycerol (pH 7.8). |
Stability And Storage |
Valid for 12 months from date of receipt when stored at -80°C.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
|
|
SARS-CoV-2 PLpro on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
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