Product Description |
Recombinant Biotinylated Cynomolgus Siglec-10 Protein is expressed from HEK293 with His tag and Avi tag at the C-terminus.It contains Thr17-Asn552. |
Product Background |
Siglec-10 is a ligand for CD52, the target of the therapeutic monoclonal antibody Alemtuzumab. It is also reported to bind to Vascular adhesion protein 1 (VAP-1) and to the co-stimulatory molecule CD24 also known as HSA (Heat-stable antigen).Siglecs (sialic acid binding Ig-like lectins) are I-type lectins that belong to the immunoglobulin superfamily. They are characterized by an N-terminal Ig-like V-type domain which mediates sialic acid binding, followed by a varying number of Ig-like C2-type domains. Siglecs 5-11 constitute the CD33/Siglec-3 related group, and are differentially expressed in the hematopoietic system. |
Product Category |
Recombinant Protein |
Target |
Siglec-10 |
Accession |
|
Species |
Cynomolgus |
Biotinylated |
yes |
Amino Acid Range |
Thr17-Asn552 |
Molecular Weight |
The protein has a predicted MW of 61.71 kDa. Due to glycosylation, the protein migrates to 72-82 kDa based on Bis-Tris PAGE result. |
Product Tag |
C-His-Avi |
Express System |
HEK293 |
Purity |
> 95% as determined by Bis-Tris PAGE |
Endotoxin |
Less than 1EU per ug by the LAL method. |
Form |
Liquid |
Shipping |
Shipped with dry ice. |
Formulation |
Supplied as 0.22 um filtered solution in 25mM MES, 150mM NaCl, 0.5M Arginine (pH 5.0). |
Stability And Storage |
Valid for 12 months from date of receipt when stored at -80°C.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
|
|
Biotinylated Cynomolgus Siglec-10 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
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