- Express System: HEK293
- Product Tag: C-hFc
- Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
- Activity: Immobilized Human GAS6, His Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Human Axl, hFc Tag with the EC50 of 9.2ng/ml determined by ELISA (QC Test). See testing image for detail.
- Amino Acid Range: Ala26-Pro449
Product Description |
Recombinant Biotinylated Human Axl Protein (Primary Amine Labeling) is expressed from HEK293 with hFc tag at the C-Terminus.It contains Ala26-Pro449. |
Product Background |
Axl, a member of the TAM (Tyro3, Axl, Mer) family, and its inhibitors can specifically break the kinase signaling nodes, allowing advanced patients to regain drug sensitivity with improved therapeutic efficacy. Overexpression and activation of Axl receptor tyrosine kinase have been widely accepted to promote cell proliferation, chemotherapy resistance, invasion, and metastasis in several human cancers, such as lung, breast, and pancreatic cancers. |
Product Category |
Recombinant Protein / Antibody discovery / Antibody discovery | Others |
Protein |
AXL |
Synonyms |
Axl; UFO; AXL oncogene; AXL; ARK; JTK11; Tyro7; AI323647; EC 2.7.10; EC 2.7.10.1 |
Accession |
|
Species |
Human |
Biotinylated |
yes |
Amino Acid Range |
Ala26-Pro449 |
Molecular Weight |
The protein has a predicted MW of 72.6 kDa. Due to glycosylation, the protein migrates to 80-110 kDa based on Bis-Tris PAGE result. |
Activity |
Immobilized Human GAS6, His Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Human Axl, hFc Tag with the EC50 of 9.2ng/ml determined by ELISA (QC Test). See testing image for detail. |
Product Tag |
C-hFc |
Expression System |
HEK293 |
Purity |
> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC |
Endotoxin |
Less than 1 EU per ug by the LAL method. |
Form |
Lyophilized |
Shipping |
Shipped at ambient temperature. |
Formulation |
Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution |
Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking. |
Stability And Storage |
-20 to -80°C for 12 months as supplied from date of receipt.;-80°C for 3 months after reconstitution.;Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
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