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Biotinylated Human CD47 Protein (CD7-HM547B) Summary
Product Description |
Recombinant Biotinylated Human CD47 Protein is expressed from HEK293 with hFc (IgG1) tag and Avi tag at the C-terminus.It contains Gln19-Pro139. |
Product Background |
CD47 (Cluster of Differentiation 47) also known as integrin associated protein (IAP) is a transmembrane protein that in humans is encoded by the CD47 gene. CD47 belongs to the immunoglobulin superfamily and partners with membrane integrins and also binds the ligands thrombospondin-1 (TSP-1) and signal-regulatory protein alpha (SIRPα).CD-47 acts as a don't eat me signal to macrophages of the immune system which has made it a potential therapeutic target in some cancers. |
Product Category |
Recombinant Protein / Antibody discovery / Immune checkpoint proteins | ADC targets |
Biotinylated Human CD47 Protein (CD7-HM547B) Specifications/Details
Protein |
CD47 |
Synonyms |
CD47 glycoprotein; CD47 molecule; CD47; IAP; OA3; MER6 |
Accession |
|
Species |
Human |
Biotinylated |
yes |
Amino Acid Range |
Gln19-Pro139 |
Molecular Weight |
The protein has a predicted MW of 42.61 kDa. Due to glycosylation, the protein migrates to 55-70 kDa based on Bis-Tris PAGE result. |
Product Tag |
C-hFc (IgG1)-Avi |
Fluorophore |
Biotin-labeled |
Expression System |
HEK293 |
Purity |
> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC |
Endotoxin |
Less than 1 EU per ug by the LAL method. |
Shipping, Reconstitution, & Storage
Form |
Lyophilized |
Shipping |
Shipped at ambient temperature. |
Formulation |
Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution |
Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking. |
Stability And Storage |
-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
Validation Images
|
|
Biotinylated Human CD47 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
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The purity of Biotinylated Human CD47 is greater than 95% as determined by SEC-HPLC. |
Other Available Proteins:
Finding available proteins...
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