Name: Biotinylated Human Fc gamma RIIIB/CD16b (NA2) Protein (FCR-HM42BB)
Brand: KactusBio
SKU: FCR-HM42BB-100UG
Price: 577.5 USD
Availability: InStock

Biotinylated Human Fc gamma RIIIB/CD16b (NA2) Protein (FCR-HM42BB)

Biotinylated Human Fc gamma RIIIB (NA2), His Tag captured on CM5 Chip via Anti-his antibody can bind Rituximab with an affinity constant of 3.50 uM as determined in SPR assay (Biacore T200).

Biotinylated Human Fc gamma RIIIB (NA2) on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

The purity of Biotinylated Human Fc gamma RIIIB (NA2) is greater than 95% as determined by SEC-HPLC.

Express System: HEK293
Product Tag: C-His-Avi
Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Activity: The affinity constant of 3.50 uM as determined in SPR assay (Biacore T200). See testing image for detail.
Amino Acid Range: Gly17-Ser200(NA2)

Catalog #FCR-HM42BB

Size

100UG

500UG

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Product Description	Recombinant Biotinylated Human Fc gamma RIIIB/CD16b (NA2) Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus.It contains Gly17-Ser200(NA2). The CD16b NA1 differ with the CD16b NA2 in AA36, 65, 82, and 106. The CD16b NA1form carries R36, N65, D82, and V106, while the CD16b NA2 form carries S36, S65, N82, and I106.
Product Background	Human Fc gamma RIIIB/CD16b Protein is a receptor for the Fc region of immunoglobulins gamma. Low affinity receptor. Binds complexed or aggregated IgG and also monomeric IgG. Contrary to III-A, is not capable to mediate antibody-dependent cytotoxicity and phagocytosis. May serve as a trap for immune complexes in the peripheral circulation which does not activate neutrophils.
Product Category	Recombinant Protein / Antibody discovery / Fc receptors

Protein	Fc gamma RIIIB/CD16b (NA2)
Synonyms	CD16; Fc gamma RIIIB; FCG3; FCGR3B; FcgRIIIB; FCRIIIB; IGFR3; CD16b (NA2); CD16B; FCG3B; FCG3; FCGR3; FCR-10; FcγRIIIB; Fc γRIIIB; Fcγ RIIIB; Fc γ RIIIB
Accession	O75015-1
Species	Human
Biotinylated	yes
Amino Acid Range	Gly17-Ser200(NA2)
Molecular Weight	The protein has a predicted MW of 23.7 kDa. Due to glycosylation, the protein migrates to 47-53 kDa based on Bis-Tris PAGE result.
Activity	The affinity constant of 3.50 uM as determined in SPR assay (Biacore T200). See testing image for detail.
Product Tag	C-His-Avi
Expression System	HEK293
Purity	> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin	Less than 1EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage	-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

	Biotinylated Human Fc gamma RIIIB (NA2), His Tag captured on CM5 Chip via Anti-his antibody can bind Rituximab with an affinity constant of 3.50 uM as determined in SPR assay (Biacore T200).
	Biotinylated Human Fc gamma RIIIB (NA2) on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
	The purity of Biotinylated Human Fc gamma RIIIB (NA2) is greater than 95% as determined by SEC-HPLC.