Biotinylated Human Her3/ErbB3 Protein (HER-HM403B)
Biotinylated Human Her3/ErbB3 Protein (HER-HM403B)
Biotinylated Human Her3/ErbB3 Protein (HER-HM403B)
Biotinylated Human Her3/ErbB3 Protein (HER-HM403B)
  • Express System: HEK293
  • Product Tag: C-His-Avi
  • Purity: > 95% as determined by Bis-Tris PAGE; > 95% as determined by HPLC
  • Activity: Immobilized Anti-Her3 Antibody, hFc Tag at 2 ug/ml (100 ul/well) on the plate. Dose response curve for Biotinylatd Human Her3, His Tag with the EC50 of 58.1 ng/ml determined by ELISA. See testing image for detail.
  • Amino Acid Range: Ser20-Thr643
Catalog #HER-HM403B
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Product Description
 Recombinant Biotinylated Human Her3/ErbB3 Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus.; It contains Ser20-Thr643.
Product Background
 Her3, also called ErbB3, is a type I membrane glycoprotein that is a member of the ErbB family of tyrosine kinase receptors.Her3 is expressed in keratinocytes, melanocytes, skeletal muscle cells, embryonic myoblasts and Schwann cells. Monomeric Her3 serves as a low affinity receptor for the heregulins (HRG).ation leads to a deletion of exons 2-7 of the EGFR gene and renders the mutant receptor incapable of binding any known ligand.
Product Category
 Recombinant Protein
Target
 Her3/ErbB3
Synonyms
 ErbB3; ErbB-3; HER3; HER3c-erbB-3; LCCS2; MDA-BF-1; MGC88033; p180-ErbB3; p45-sErbB3; p85-sErbB3; ERBB3
Accession
Species
 Human
Biotinylated
 yes
Amino Acid Range
 Ser20-Thr643
Molecular Weight
 The protein has a predicted MW of 71.6 kDa. Due to glycosylation, the protein migrates to 90-100 kDa based on Bis-Tris PAGE result.
Activity
 Immobilized Anti-Her3 Antibody, hFc Tag at 2 ug/ml (100 ul/well) on the plate. Dose response curve for Biotinylatd Human Her3, His Tag with the EC50 of 58.1 ng/ml determined by ELISA. See testing image for detail.
Product Tag
 C-His-Avi
Express System
 HEK293
Purity
 > 95% as determined by Bis-Tris PAGE; > 95% as determined by HPLC
Endotoxin
 Less than 1 EU per ug by the LAL method.
Form
 Lyophilized
Shipping
 Shipped at ambient temperature.
Formulation
 Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution
 Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage
 Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Immobilized Anti-Her3 Antibody, hFc Tag at 2 ug/ml (100 ul/well) on the plate. Dose response curve for Biotinylatd Human Her3, His Tag with the EC50 of 58.1 ng/ml determined by ELISA.
Immobilized Biotinylated Human Her3, His Tag at 2 ug/ml (100 ul/well) on the streptavidin precoated plate (5 ug/ml). Dose response curve for Human NRG1 Beta 1, hFc Tag with the EC50 of 8.3 ng/ml determined by ELISA (QC Test).
Biotinylated Human Her3 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
The purity of Biotinylated Human Her3 is greater than 95% as determined by SEC-HPLC.
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