Name: Canine CD40/TNFRSF5 Protein (CD4-DM140)
Brand: KactusBio
SKU: CD4-DM140-100UG
Price: 346.5 USD
Availability: InStock

Express System: HEK293
Product Tag: C-His
Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Activity: Immobilized Canine CD40, His Tag at 5ug/ml (100ul/well) on the plate. Dose response curve for Human/Cynomolgus/Rhesus macaque CD40 Ligand Trimer, hFc Tag with the EC50 of 29.4ng/ml determined by ELISA (QC Test).
Amino Acid Range: Glu21-Ala194

Catalog #CD4-DM140

Size

100UG

500UG

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Canine CD40/TNFRSF5 Protein (CD4-DM140) Summary

Product Description	Recombinant Canine CD40/TNFRSF5 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Glu21-Ala194.
Product Background	CD40 is a costimulatory protein found on antigen presenting cells and is required for their activation. The binding of CD154 (CD40L) on TH cells to CD40 activates antigen presenting cells and induces a variety of downstream effects.CD40 molecule is a potential target for cancer immunotherapy. There are number of completed and ongoing clinical trials where agonistic anti-CD40 monoclonal antibodies are employed to activate an anti-tumor T cell response via activation of dendritic cells.
Product Category	Recombinant Protein / Antibody discovery / Immune checkpoint proteins

Canine CD40/TNFRSF5 Protein (CD4-DM140) Specifications/Details

Protein	CD40/TNFRSF5
Synonyms	CD40; CD40L receptor;- TNFRSF5; CD40 antigen; CD40 molecule; CDw40; MGC9013;
Accession	Q7YRL5
Species	Canine
Biotinylated	no
Amino Acid Range	Glu21-Ala194
Molecular Weight	The protein has a predicted MW of 20.14 kDa. Due to glycosylation, the protein migrates to 30-40 kDa based on Bis-Tris PAGE result.
Activity	Immobilized Canine CD40, His Tag at 5ug/ml (100ul/well) on the plate. Dose response curve for Human/Cynomolgus/Rhesus macaque CD40 Ligand Trimer, hFc Tag with the EC50 of 29.4ng/ml determined by ELISA (QC Test).
Product Tag	C-His
Fluorophore	Unconjugated
Expression System	HEK293
Purity	> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin	Less than 1 EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking.
Stability And Storage	-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

	Immobilized Canine CD40, His Tag at 5ug/ml (100ul/well) on the plate. Dose response curve for Human/Cynomolgus/Rhesus macaque CD40 Ligand Trimer, hFc Tag with the EC50 of 29.4ng/ml determined by ELISA (QC Test).
	Canine CD40 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
	The purity of Canine CD40 is greater than 95% as determined by SEC-HPLC.

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